N.G. PRIKHODCHENKO¹, E.S. ZERNOVA¹, T.A. SHUMATOVA¹, A. NI¹, D.V. KOVALENKO¹

 ¹Pacific State Medical University, Vladivostok 

 Contact details:

Prikhodchenko N.G. — MD, Professor at the Institute for Pediatrics

Address: 2 prospekt Ostryakova, Vladivostok, Russian Federation, 690002, tel.: +7-924-521-30-67, e-mail: prikhodchenko_n@mail.ru

In order to study the role of glutathione transferase genes polymorphism in the formation of increased epithelial permeability syndrome in children with food allergy, we examined 39 young children (from 1.5 months to 3 years, group I) with a gastrointestinal form of food allergy and 30 healthy children with an uncomplicated anamnesis, comparable in sex and age (control group). It was found the association of alleles — /del of the GSTM1 gene and Ile105/Ala114 of the GSTP1 gene — with the development of increased epithelial permeability syndrome in food allergies in children. The obtained associations indirectly indicate the contribution of disturbances in the glutathione transferase system in children with gastrointestinal forms of food allergy both in terms of the syndrome of increased epithelial permeability formation and the comorbid pathology development.

Key words: epithelial permeability, food allergy, children, xenobiotic biotransformation system, genes polymorphism of glutathione-S-transferase.

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