Genetic mechanisms of aspirin resistance in patients with atherothrombotic variant of ischemic stroke
T.E. EVERSTOVA1, T.YA. NIKOLAEVA2, S.A. CHUGUNOVA2
1Republic Hospital No. 2 — Center for Emergency Medical Aid, Yakutsk
2North-Eastern Federal University named after M.K. Ammosov, Yakutsk
Contact details:
Everstova T.E. — post-graduate student of the Department of Neurology and Psychiatry
Address: 58 Belinsky St., Yakutsk, Russian Federation, 677000, tel.: +7-914-227-68-19, e-mail: selectir_66@mail.ru
The purpose — to study the association of rs2317676 polymorphic variants of the GPIIIa gene with the development of aspirin resistance in patients with atherothrombotic variant of ischemic stroke.
Material and methods. The article presents data of 100 patients with acute ischemic stroke and 100 people from the control group. All the patients received aspirin at a dose of 300 mg per day during the first day of the disease and 100 or 125 mg per day thereafter. The control group received aspirin as a primary prophylaxis for cardiovascular diseases. The study measured platelet aggregation on day 5–7 of taking the drug. The rs2317676 polymorphism of the GPIIIa gene was considered as genetic marker.
Results. The frequency of A/G polymorphism rs2317676 of the GPIIIa gene was lower among individuals with low platelet aggregation compared to individuals with high platelet aggregation (p = 0.023; OR = 0.33; 95% CI: 0.13–0.89).
Conclusion. Carriage of the A/G genotype rs2317676 polymorphism of the GPIIIa gene influences an increase in platelet aggregation and the development of aspirin resistance.
Key words: ischemic stroke, aspirin, aspirin resistance, genetic polymorphisms.
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