Features of virus infection COVID-19 during the pregnancy
I. SHEVELEVA, A.V. ROMANOVSKAYA, N.F. KHVOROSTUKHINA
Saratov State Medical University named after V.I. Razumovsky, Saratov
Contact details:
Sheveleva D.I. — post-graduate student of the Department of Obstetrics and Gynecology of the Pediatric Faculty
Address: 112 Bolshaya Kazachya St., Russian Federation, Saratov, 410012, : +7-927-125-14-47, e-mail: sheveleva_darya@mail.ru
The purpose of the research was to study the features of the clinical course of COVID-19 viral infection in pregnant women, depending on the gestational stage.
Material and methods. Included the study of 67 pregnant women with COVID-19 at different periods of gestation. The age of women ranged from 16 to 41 years. All pregnant women were hospitalized to the infectious diseases departments of Saratov hospitals. During the period of hospitalization, the examination of women was carried out according to the methodological recommendations of the Ministry of Health of Russia for coronavirus infection in pregnant women. During virological examination of mucus from the pharynx and nose, using the reverse transcription polymerase chain reaction method, the RNA of the COVID-19 virus was found in all pregnant women.
Results. COVID-19 most frequently infects primipara in the I (61,6%) and III (70,6%) trimester of gestation and multipara in the II (62,5%) trimester of gestation with burdened obstetrics-gynecological anamnesis (58,3%) and accompanying pathologies (41,5%). In pregnant women with COVID-19, mild and intermediate forms of the disease prevailed (31,3% and 47,8% respectiely). The frequency of coronavirus infection in the I (38,8%) and II (35,8%) trimesters of gestation increases the frequency of that in the III (25,3%) trimester. Among women with COVID-19, the following symptoms were observed: decrease in smell and taste in 66 (98,5%) cases, sore throat in 59 (85%) cases, increased body temperature in 61 (90,9%) cases. Lesions of lower respiratory tract was observed in all stages of gestation, pneumonias were less frequent in the I trimester. In all cases the COVID-19 course had a favorable outcome, with no lethality.
Key words: pregnancy, COVID-19, gestation stages, iruses, intoxication, shortness of breath, pneumonia.
REFERENCES
- Salov I.A., Romanovskaya A.V., Mikhaylova E.V. The problem of ARVI and influenza A (H1N1SWIN) in modern obstetrics. Saratovskiy nauchno-meditsinskiy zhurnal, 2012, vol. 8, no. 2, pp. 218–223 (in Russ.).
- Belokrinitskaya T.E., Shapovalov K.G. Gripp i beremennost’ [Influenza and pregnancy]. Moscow: GEOTAR-Media, 2016. 144 p.
- Metodicheskie rekomendatsii organizatsii okazaniya meditsinskoy pomoshchi beremennym, rozhenitsam, rodil’nitsam i novorozhdennym pri novoy koronavirusnoy infektsii COVID-19. MZ RF. Versiya 1 ot 24.04.2020 [Guidelines for the organization of medical care for pregnant women, women in labor, parturient women and newborns with a new coronavirus infection COVID-19. Ministry of Health of the Russian Federation. Version 1 from 04/24/2020]. 60 p.
- Liu H., Liu F., Li J., Zhang T. et al. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect, 2020, Mar 20. pii: S0163-4453(20)30118-3.
- Vremennye metodicheskie rekomendatsii po profilaktike, diagnostike i lecheniyu novoy koronavirusnoy infektsii 2019-nCoV. MZ RF. Versiya 8.1 ot 01.10.2020 [Interim guidelines for the prevention, diagnosis and treatment of the new 2019-nCoV coronavirus infection. Ministry of Health of the Russian Federation. Version 8.1 from 10/01/2020]. 227 p.
- Ambulatornoe obsledovanie i vedenie beremennykh zhenshchin s podozreniem ili podtverzhdennym COVID-19. Algoritm ACOG/SMFM, 2020 [Outpatient examination and management of pregnant women with suspected or confirmed COVID-19. ACOG / SMFM algorithm, 2020].
- Liu D. et al. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol, 2020, March, 18, pp. 1–6. DOI: 10.2214/AJR.20.23072
- Capanna F., Haydar A., McCarey C., Bernini Carri E., Bartha Rasero J., Tsibizova V., Helmer H., Makatsarya A., Di Renzo G.C. Preparing an obstetric unit in the heart of the epidemic strike of COVID-19: quick reorganization tips. J Matern Fetal Neonatal Med, 2020, April 12, pp. 1–7. DOI: 10.1080/14767058.2020.1749258