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  • Features of trace element composition of the blood in sarcoidosis patients

    Редакция | 2013, Original articles, Practical medicine 05 (13) Pulmonology. Antimicrobial therapy | 18 октября, 2013

    O.A. DENISOVA, K.K. EGOROVA, G.E. CHERNOGORYUK, N.V. BARANOVSKAYA, L.P. RIKHVANOV, G.M. CHERNYAVSKAYA, A.N. GOLOSCHAPOVA
    Tomsk Regional Clinical Hospital
    Siberian Medical University, Tomsk
    National Research Tomsk Polytechnic University

    Denisova Olga Aleksandrovna
    Candidate of Medical Science, pulmonologist at the diagnostic polyclinic
    101 Rozy Luksemburg Str., apt.198, Tomsk 634026
     tel. 8-952-883-64-83, e-mail: oadeni@yandex.ru

    The results of the study of chemical elements (Ca, Sc, Cr, Fe, Co, Zn, Br, Rb, Ag, Ba, Sr, Nd, As, Au, La, Th, U, Hf, Cs, Tb, Ta, Sm, Eu, Yb, Lu) by instrumental neutron activation analysis of the blood of 109 patients with onset of sarcoidosis versus control (28 people) are presented in the article. In blood of patients with sarcoidosis was found low content of Sc, Fe, Co, Zn, Rb (p <0.001), high content of Th (p<0.001), La (p<0.003). There are associations of these elements with the blood formed elements and immune status parameters. No significant correlations between chemical elements and the degree of dyspnea, respiratory functions, radiological disease states, age, frequency of regression or progression, smoking and using drugs were found. High level of lanthanum and hafnium may contribute to the formation of granulomatous reactions in the body. This characteristic may have a local value in the studied region. Influence of these trace elements on the development of sarcoidosis is mediated by action on blood cells and immune processes in the body.

    Key words: sarcoidosis, trace elements, neutron activation analysis.

     

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    Метки: A.N. GOLOSCHAPOVA, G.E. CHERNOGORYUK, G.M. CHERNYAVSKAYA, K.K. EGOROVA, L.P. RIKHVANOV, N.V. BARANOVSKAYA, neutron activation analysis, O.A. DENISOVA, Practical medicine 05 (13) Pulmonology. Antimicrobial therapy, sarcoidosis, trace elements

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