Features of metabolic processes in lymphocytes in patients with viral infections
E.P. TIKHONOVA, I.V. SERGEYEVA, N.I. KAMZALAKOVA, Yu.S. TIKHONOVA
Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskiy, 1 Partizan Zheleznyak St., Krasnoyarsk, Russian Federation, 660022
Tikhonova E.P. — D. Med. Sc., Professor, Head of the Department of Infectious Diseases and Epidemiology with a course of Postdegree Education, tel. (8391) 246-93-75, e-mail: tihonovaep@mail.ru
Sergeyeva I.V. — Cand. Med. Sc., Associate Professor of the Department of Infectious Diseases and Epidemiology with a course of Postdegree Education, tel. (8391) 246-93-75, e-mail: sergeevaiv-1979@mail.ru
Kamzalakova N.I. — D. Med. Sc., Professor, Head of the Department of Clinical Immunology, tel. (8391) 246-93-75, e-mail: kaniala@mail.ru
Tikhonova Yu.S. — Assistant Lecturer the Department of Infectious Diseases and Epidemiology with a course of Postdegree Education, tel. (8391) 246-93-75, e-mail: tihonovaus-1981@mail.ru
The article presents results of a survey of 63 patients with virus infections (flu and chicken pox). The assessment of character and intensity of metabolic processes in lymphocytes of patients with virus infections by the changes of intracellular enzymes activity showed that at the peak of disease the intensification of glycolysis reactions is noted, together with substantial increase of functional load on cells. There is a considerable decrease in intensity of reactions at the initial stage of a tricarbonic acid cycle that has to reduce power efficiency of the cycle, as well as intensive receipt of metabolites to supply the tricarbonic acid cycle with substrata from amino acid exchange, providing the raised transport of amino acids in lymphocytes. Application of preparations of amber acid or its salts gives additional substrate saturation of tricarbonic acid cycle, increasing energy efficiency of the cycle and functionality of lymphocytes.
Key words: flu, chicken pox, lymphocytes, metabolic processes, functional cellular overload, substrate.
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