A.A. TYAZHEVA, D.V. PECHKUROV

Samara State Medical University, 89 Chapaevskaya St., Samara, Russian Federation, 443099

Tyazheva A.A. — Cand. Med. Sc., Assistant Lecturer of the Pediatrics Department, tel. (846) 959-45-11, e-mail: aatyajeva@mail.ru

Pechkurov D.V. — D. Med. Sc., Professor of the Pediatrics Department, tel. (846) 959-45-11, e-mail: dmpechkurov@yandex.ru

The article presents the results of a survey of 122 children with functional dyspepsia. From the standpoint of the biopsychosocial model of the formation of functional disorders, the role of Helicobacter pylori in the development of abdominal pain was studied. It was found that in children not infected with Helicobacter pylori and infected with CagA-negative strains, non-gastrointestinal factors dominate in the functional dyspepsia pathogenesis, while in children with CagA-positive strains of Helicobacter pylori, inflammatory factors dominate, which violate the mucosal homeostasis.

Key words: children, functional dyspepsia, biopsychosocial model, Helicobacter pylori, CagA-antigen.

REFERENCES

1. Pechkurov D.V. Epidemiology of gastrointestinal diseases in children: a retrospective analysis of the accuracy. Pediatriya. Zhurnal im. G.N. Speranskogo, 2004, no. 2, pp. 4-8 (in Russ.).

2. Shcherbakov P.L., Zvyagin A.A., Pechkurov D.V. et al. The issues of functional dyspepsia in children and adolescents. Pediatriya, 2007, vol. 1, pp. 12-18(in Russ.).

3. Pakhomova I.A. Psikhologicheskiy status i dinamika techeniya funktsional’noy dispepsii u shkol’nikov po dannym prospektivnogo nablyudeniya. Aspirantskiy vestnik Povolzh’ya, 2010, no. 7-8, pp. 121-126 (in Russ.).

4. Drossman D.A., Corazziari E., Talley N.J. et al. Rome II: a multinational consensus document on functional gastrointestinal disorders, 1999.

5. Pechkurov D.V., Tyazheva A.A., Allenova Yu.E., Shakhmatova E.A. The biopsychosocial model of functional disorders of the gastrointestinal tract: what’s new in the etiology, pathogenesis, diagnosis and treatment? Voprosy detskoy dietologii, 2014, vol. 12, no. 1, pp. 61-65 (in Russ.).

6. Nabwera H.M., Logan R.P. Epidemiology of Helicobacter pylori: transmission, translocation and extragastric reservoirs . J. Physiol. Pharmacol, 1999, vol. 50, no. 5, rr. 723-733.

7. Belousov S.Yu. Morfologicheskaya i klinicheskaya kharakteristika etiopatogeneticheskie aspekty khronicheskogo gastrita i detey i podrostkov: avtoref. dis. … kand. med. nauk [Morphological and clinical characteristics etiopathogenetical aspects of chronic gastritis and children and adolescents. Synopsis of dis. PhD med. sciences]. Chelyabinsk, 1999. 24 p.

8. Solodovnik A.G. Features motor-tonic disorders of gastric and duodenal ulcers in patients with chronic gastritis and gastroduodenitis in adolescents. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii, 1998, vol. VIII, no. 5, p. 228.

9. Ustyan L.A. H.pylori-assotsiirovannyy gastrit i sindrom funktsional’noy dispepsii u detey podrostkovogo vozrasta: dinamika morfologicheskikh i immunogistokhimicheskikh pokazateley slizistoy obolochki zheludka v usloviyakh eradikatsionnoy terapii: avtoref. dis. … kand. med. nauk [H.pylori-associated gastritis and functional dyspepsia syndrome in children of teenage age: the dynamics of morphological and immunohistochemical parameters of the gastric mucosa in terms of eradication therapy. Synopsis of dis. PhD med. sciences]. Omsk, 2005. 24 p.

10. Aruin L.I. Active chronic gastritis and Helicobacter pylori. Arkhiv patologii, 1994, vol. 56, no. 1, pp. 29-33 (in Russ.).

11. Tsimmerman Ya.S. “Rome criteria-III” functional (gastroduodenal) dyspepsia. Klinicheskaya meditsina, 2008, no. 4, pp. 59-65 (in Russ.).

12. Sheptulin A.A. Infection with Helicobacter pylori – pathogenetic factor of many diseases? How to diagnose and how to treat? Vrach, 2006, no. 7, pp. 7-8 (in Russ.).

13. Current European concepts in management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter pylori Study Group. Gut, 1997, vol. 41, pp. 8-13.

14. Korsunskiy A.A. Khelikobakterioz i bolezni organov pishchevareniya u detey [Helicobacter pylori infection and gastrointestinal diseases in children]. Moscow: Medpraktika-M, 2002. 168 p.

15. CagA cytotoxic strains of Helicobacter pylori and interleukin-8 in Gastric epithelial cells. J. Clin Pathol, 1994, 47, pp. 945-950.

16. Isakov V.A. Molecular and genetic basis of pathogenicity of Helicobacter pylori. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii, 2002, vol. 12, no. 6, pp. 82-85.