Experimental substantiation of application of sulfated glycosaminoglycans (sGAG) solution in the treatment of corneal toxic erosion in rabbits
A.V. TERESCHENKO1, Yu.A. BELYY1, E.Kh. TAKHCHIDI2, S.V. NOVIKOV3, N.V. MAYCHUK2, G.Yu. USANOVA2
1Kaluga branch of the Interbranch scientific and technical complex «Eye Microsurgery» named after acad. S.N. Fedorov, 5 Sv. Fedorov St., Kaluga, Russian Federation, 248007
2The Interbranch scientific and technical complex «Eye Microsurgery» named after acad. S.N. Fedorov, 59a Beskudnikovsky Blvd., Moscow, Russian Federation, 1274743Research and experimental production «Eye Microsurgery», 59a Beskudnikovsky Blvd., bld. В, Moscow, Russian Federation, 127474
Tereschenko A.V. — D. Med. Sc., Branch Director, tel. (4842) 505-795, e-mail: nauka@mntk.kaluga.ru
Belyy Yu.A. — D. Med. Sc., Professor, Deputy Director for Science Work, tel. (4842) 505-767, e-mail: nauka@mntk.kaluga.ru
Takhchidi E.Kh. — Cand. Med. Sc., ophthalmologist of the Department of Glaucoma Surgery, tel. (499) 488-89-06, e-mail: takhchidie@yandex.ru
Novikov S.V. — Deputy Director, tel. (499) 488-89-06, e-mail: snovikov@yandex.ru
Maychuk N.V. — Cand. Med. Sc., ophthalmologist of the Department of Refractive Laser Surgery, Senior Researcher, tel. (499) 488-89-06, e-mail: drmaichuk@yandex.ru
Usanova G.Yu. — postgraduate student, tel. (499) 488-89-06, e-mail: usanova-fit@mail.ru
The article presents the results of investigation of corneal reparative activity and protective effect of 0.5% mixture of sulfated glycosaminoglicans (sGAG) on experimental model of corneal toxic erosion. The terms of complete epithelisation and restoration of the corneal cyto-architecture in the 2nd experimental group (0.5% sGAG) (10.66±2.58 hours), compared to the control group (0.9% NaCL) (119.33±27.73 hours) indicate the expressed regenerative features of sGAG, while the correlation of the indicators in the 1st experimental group (0.1% BC + 0.5% sGAG) and the control group allow to suspect the presence of protective features of sGAG solution in conditions of toxic impact of benzalkonium chloride.
Key words: cornea, benzalkonium chloride, sulfated glycosaminoglycans, toxicity.