A.V. TERESCHENKO¹, Yu.A. BELYY¹, E.Kh. TAKHCHIDI², S.V. NOVIKOV³, N.V. MAYCHUK², G.Yu. USANOVA²

¹Kaluga branch of the Interbranch scientific and technical complex «Eye Microsurgery» named after acad. S.N. Fedorov, 5 Sv. Fedorov St., Kaluga, Russian Federation, 248007

²The Interbranch scientific and technical complex «Eye Microsurgery» named after acad. S.N. Fedorov, 59a Beskudnikovsky Blvd., Moscow, Russian Federation, 127474³Research and experimental production «Eye Microsurgery», 59a Beskudnikovsky Blvd., bld. В, Moscow, Russian Federation, 127474

Tereschenko A.V. — D. Med. Sc., Branch Director, tel. (4842) 505-795, e-mail: [email protected]

Belyy Yu.A. — D. Med. Sc., Professor, Deputy Director for Science Work, tel. (4842) 505-767, e-mail: [email protected]

Takhchidi E.Kh. — Cand. Med. Sc., ophthalmologist of the Department of Glaucoma Surgery, tel. (499) 488-89-06, e-mail: [email protected]

Novikov S.V. — Deputy Director, tel. (499) 488-89-06, e-mail: [email protected]

Maychuk N.V. — Cand. Med. Sc., ophthalmologist of the Department of Refractive Laser Surgery, Senior Researcher, tel. (499) 488-89-06, e-mail: [email protected]

Usanova G.Yu. — postgraduate student, tel. (499) 488-89-06, e-mail: [email protected]

The article presents the results of investigation of corneal reparative activity and protective effect of 0.5% mixture of sulfated glycosaminoglicans (sGAG) on experimental model of corneal toxic erosion. The terms of complete epithelisation and restoration of the corneal cyto-architecture in the 2^nd experimental group (0.5% sGAG) (10.66±2.58 hours), compared to the control group (0.9% NaCL) (119.33±27.73 hours) indicate the expressed regenerative features of sGAG, while the correlation of the indicators in the 1^st experimental group (0.1% BC + 0.5% sGAG) and the control group allow to suspect the presence of protective features of sGAG solution in conditions of toxic impact of benzalkonium chloride.

Key words: cornea, benzalkonium chloride, sulfated glycosaminoglycans, toxicity.