A.N. GAYNETDINOVA¹, L.N. ZALYALYUTDINOVA¹, D.I. ABDULGANIEVA¹, A.Ya. IMANAEVA², A.N. GAYFULLIN³

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

²JSC «Tatkhimfarmpreparaty», 260 Belomorskaya St., Kazan, Russian Federation, 420091

³Main bureau of medical and social assessment for the Republic of Tatarstan, 71 Mazit Gafuri St., Kazan, Russian Federation, 420108

Gaynetdinova A.N. — postgraduate student of the Department of Hospital Therapy with a course of Endocrinology, tel. +7-987-414-14-05, e-mail: alsu.doc@mail.ru

Zalyalyutdinova L.N. — D. Med. Sc., Professor of Department of Pharmacology, tel. (843) 296-86-00. e-mail: alsu.doc@mail.ru

Abdulganieva D.I. — D. Med. Sc., Associate Professor, Head of the Department of Hospital Therapy, tel. (843) 237-34-84, e-mail: Diana_s@mail.ru

Imanaeva A.Ya. — Cand. Med. Sc., medical advisor, tel. +7-987-290-30-72, e-mail: a.y.imanaeva@gmail.com

Gayfullin A.N. — Head of the staff, Doctor of Medical and Social Expertise, tel. +7-904-766-17-66. e-mail: airat—vrach@mail.ru

This article presents the results of studying of the efficiency of combined of adjuvant-induced arthritis with methotrexate (1 mg/kg intraperitoneally 1 time per week) and thioctic acid (11 mg/kg intraperitoneally daily) versus monotherapy with both medication. We chouse the following criteria for experimental therapy efficiency evaluation: oncometric method for determination of the volume of inflamed paws in the dynamics, hind limbs X-ray examination and blood test in the end of the 1-month course of therapy. We found that combined use of thioctic acid with MTX inhibits adjuvant-induced intensity of edema, prevented erosions, deformations of the joints of rats, normalized amount of leukocytes and erythrocyte sedimentation rate in peripheral blood in comparison with methotrexate monotherapy.

Key words: adjuvant arthritis, thioctic acid, methotrexate, rats, therapy.

REFERENCES

1. Nasonov E.L., Karataev D.E., Balabanova R.M. Revmatoidnyy artrit [Rheumatoid arthritis]. Revmatologiya: natsional’noe rukovodstvo. Moscow: GEOTAR-Media, 2008. Part 12. Pp. 290-331.
2. Lila A.M. Socio-economic aspects of Rheumatic diseases. Rus. Med. Zhurn., 2006, no. 5, pp. 1033-1039 (in Russ.).
3. Shulutko B.I. Revmatoidnyy artrit [Rheumatoid arthritis]. Standarty diagnostiki i lecheniya vnutrennikh bolezney. Saint Petersburg: OOO “Medkniga ELBI-SPb”; Renkor, 2009. Pp. 478-489.
4. Zalyalyutdinova L.N., Nasybullina N.M., Zakhmatova E.Yu., Zverev R.R., Fattakhova A.Ya., Sadreev I.A. Sravnitel’naya otsenka protivovospalitel’noy aktivnosti kisloty lipoevoy i diklofenaka natriya [Comparative evaluation of anti-inflammatory activity of lipoic acid and diclofenac sodium]. Materialy II mezhdunarodnoy konferentsii «Mediko-sotsial’naya ekologiya lichnosti: sostoyanie i perspektivy», 2-3 aprelya 2004 g. Minsk, 2004. Pp. 168-169.
5. Zvereva E., Zalyalyutdinova L.N., Zverev R., Garaev R. Estimation antipyretic, anti-inflammatory and analgesic activity of lipoic acid. Fundamental pharmacology and pharmacy – clinical practice. Materials of the 2nd Russian-Chinese international scientific conferences on pharmacology. Perm, 2006. Pp. 65-67.
6. Baraboy V.A. Alpha-lipoic acid, dihydrolipoic-active bioantioksidantnaya and bioregulatory system. Ukr. biokhm. zhurnal, 2005, vol. 77, no. 3, pp. 20-26 (in Russ.).
7. Abdel-Zaher A.O., Mahmoud M.M. et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology, 2008, Jan 20, 243 (3), pp. 261-70.
8. Yudoh K. et al. Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis. Int. J. Nanomedicine, 2009, no. 4, pp. 217-225.
9. Zalyalyutdinova L.N., Sabirova A.Ya., Nasybullina D.A. Razrabotka novogo patogeneticheskogo podkhoda k lecheniyu revmatoidnogo artrita [Development of new pathogenetic approach to treatment of rheumatoid arthritis]. Innovatsiya RAN-2010. Materialy ezhegodnoy nauchno-prakticheskoy konferentsii, 2010. Pp. 243-246.