A.N. GAYNETDINOVA¹, L.N. ZALYALYUTDINOVA¹, D.I. ABDULGANIEVA¹, A.Ya. IMANAEVA², A.N. GAYFULLIN³

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

²JSC «Tatkhimfarmpreparaty», 260 Belomorskaya St., Kazan, Russian Federation, 420091

³Main bureau of medical and social assessment for the Republic of Tatarstan, 71 Mazit Gafuri St., Kazan, Russian Federation, 420108

Gaynetdinova A.N. — postgraduate student of the Department of Hospital Therapy with a course of Endocrinology, tel. +7-987-414-14-05, e-mail: [email protected]

Zalyalyutdinova L.N. — D. Med. Sc., Professor of Department of Pharmacology, tel. (843) 296-86-00. e-mail: [email protected]

Abdulganieva D.I. — D. Med. Sc., Associate Professor, Head of the Department of Hospital Therapy, tel. (843) 237-34-84, e-mail: [email protected]

Imanaeva A.Ya. — Cand. Med. Sc., medical advisor, tel. +7-987-290-30-72, e-mail: [email protected]

Gayfullin A.N. — Head of the staff, Doctor of Medical and Social Expertise, tel. +7-904-766-17-66. e-mail: airat—[email protected]

This article presents the results of studying of the efficiency of combined of adjuvant-induced arthritis with methotrexate (1 mg/kg intraperitoneally 1 time per week) and thioctic acid (11 mg/kg intraperitoneally daily) versus monotherapy with both medication. We chouse the following criteria for experimental therapy efficiency evaluation: oncometric method for determination of the volume of inflamed paws in the dynamics, hind limbs X-ray examination and blood test in the end of the 1-month course of therapy. We found that combined use of thioctic acid with MTX inhibits adjuvant-induced intensity of edema, prevented erosions, deformations of the joints of rats, normalized amount of leukocytes and erythrocyte sedimentation rate in peripheral blood in comparison with methotrexate monotherapy.

Key words: adjuvant arthritis, thioctic acid, methotrexate, rats, therapy.

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