L.T. BAYAZITOVA^1, 2, O.F. TYUPKINA¹, T.A. CHAZOVA¹, M.S. RODIONIOVA¹, R.I. ANAMOV², O.I. POPTSOV², I.R. VALIULLINA³, Z.Z. NASYBULLOVA³

 ¹Kazan Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, Kazan

²Kazan State Medical University, Kazan

³Republic Clinical Hospital, Kazan

Contact details:

Bayazitova L.T. — PhD (medicine), leading researcher, Head of Microbiology Research Laboratory, Associate Professor of Microbiology Department named after Academician V.M. Aristovskiy

Address: 67 Bolshaya Krasnaya St., Kazan, Russian Federation, 420015, tel.: +7 (843) 236-67-91, e-mail: bajalt@mail.ru

 Streptococcus pneumoniae and Klebsiella pneumoniae are opportunistic pathogens, commensals; at the same time, they can cause life-threatening infections. These bacteria have a plastic genome and can evade the host’s immune response. Antibiotic-resistant strains are of particular concern. The use of bacteriophages is considered as an alternative or adjunct to antimicrobial therapy. Sensitivity to antimicrobial drugs and to bacteriophages of 70 strains of Klebsiella pneumonia was studied, which were isolated from Streptococcus pneumoniae carriers who applied for diagnostic research in consultation and diagnostic polyclinic of Kazan Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor. Based on the results of phagolysability of K. pneumoniae isolates with different sensitivity profiles to antimicrobial drugs, phage preparations were ranked in the following sequence (as activity decreases): Klebsiella bacteriophage polyvalent purified > Pyobacteriophage complex > sextaphage.

Key words: carriage, Streptococcus pneumoniae, Klebsiella pneumoniae, antibiotic resistance, bacteriophages.

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