O.V. SKOROKHODKINA¹, A.V. LUNTSOV², S.A. ARKHIPOVA¹

¹Kazan State Medical University, Kazan

²Republican Clinical Hospital of the MH of RT, Kazan

 Contact:

Skorokhodkina O.V. ― MD, Head of the Department of Clinical Immunology and Allergology

Address: 49 Butlerov Str., Kazan, Russian Federation, 420012, tel. +7-917-392-50-45, e-mail: [email protected] 

Objective ― to evaluate the comparative efficacy and safety of allergen-specific immunotherapy in patients with allergic rhinitis and bronchial asthma.

Material and methods. Medical documentation was analyzed of patients with validated questionnaires and scales during the application of allergen-specific immunotherapy for 3 years in 111 patients with allergic rhinitis and bronchial asthma. Statistical processing of the data was carried out using the software package Statistica 10.0.

Results. According to the results of the analysis of validated questionnaires, the clinical efficacy parameters of SCIT and SLIT after a year, two and three years of therapy, were comparable. At the end of the 3rd year of SCIT, the average score on the CSMS scale for patients with AR was 1.25, and SLIT was 0 points. The average CARAT10 score in patients with a combination of AD and AR after 3 years of therapy significantly increased both in the group of patients receiving SCIT and SLIT. When conducting SCIT, local adverse reactions were observed in 5 patients (4.5%), and when using SLIT in 3 patients (less than 1%).

Conclusion. Efficacy of SCIT and SLIT in patients of both groups was comparable (p>0.05). However, the best tolerance of SLIT and the possibility of it being carried out outside the treatment and prophylactic activity increased the patients’ compliance.

Key words: bronchial asthma, allergic rhinitis, allergen-specific immunotherapy.

(For citation: Skorokhodkina O.V., Luntsov A.V., Arkhipova S.A. Estimation of the efficiency of allergen-specific immunotherapy in patients with atopic asthma and allergic rhinitis. Practical medicine. 2019. Vol. 17, № 6 (part 1), P. 44-48)

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