P.V. POPRYADUKHIN^1,3, G.I. POPOV², I.P. DOBROVOLSKAYA^1,3, V.E. YUDIN^1,3, V.N. VAVILOV², G.Yu. YUKINA², E.M. IVANKOVA^1,3

¹Institute of Macromolecular Compounds of the Russian Academy Of Science, 31 Bolshoy driveway, Saint Petersburg, Russian Federation, 199004

²Pavlov First Saint Petersburg State Medical University, 6-8 Lev Tolstoy Str., Saint Petersburg, Russian Federation, 197022

³Saint Petersburg Polytechnic University of Peter the Great, 29 Politekhnicheskaya Str., Saint Petersburg, Russian Federation, 195251

 Popryadukhin P.V. ― Cand. Engineering Sc., Senior Researcher, e-mail: pavel-pn@mail.ru

 In order to create a tissue-engineering vascular implant for pediatric vascular surgery, a matrix of nanofibres was obtained by electroforming using an aliphatic copolyamide. It was shown to have high mechanical properties (strength 7.5 MPa, elongation at break 299%). Its barrier properties were sufficient for implantation into vessels. Biological safety and biocompatibility of the matrix were proved in experiments with mesenchymal stem cells. Chronic experiments in vivo up to 14 months were carried out on rats’ abdominal aortae. The patency of the grafts was satisfactory (71%). According to histological examination, graft integration occurs with the formation of neointima, without signs of inflammation and myointimal hyperplasia in the anastomosis zone.

Key words: tissue engineering, matrix, nanofibers, aliphatic copolyamide.

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