R.I. SADIKOVA, E.G. MUTALOVA

 Bashkir State Medical University, 3 Lenin Str., Ufa, Russian Federation, 450000

Sadikova R.I. — Assistant Lecturer of the Department of Hospital Therapy №1, tel. (347) 260-40-07, e-mail: [email protected], ORCID ID: 0000-0002-6653-9194

Mutalova E.G. — D. Sc. (medicine), Professor, Head of the Department of Hospital Therapy №1, tel. (347) 260-40-07, e-mail:[email protected], ORCID ID: 0000-0002-7454-9819

To study the effect of cytokine regulation on the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), monocyte-macrophage factors (VEGF, MCP-1), and intercellular adhesion molecules (sVCAM-1, sP-selectin) on endothelial dysfunction in persons with acute myocardial infarction.

Material and methods. Patients with acute myocardial infarction were examined. Along with anamnesis, a clinical examination was conducted. Immunoenzymes (VEGF, MCP-1), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), molecular adhesion level (sVCAM-1, sP-selectin) were studied; analysis of association of the polymorphic locus of the enzyme that controls the content of NO (NOS3) was conducted.

Results. The level of pro-inflammatory cytokines reliably increased (p<0,05) in patients with acute myocardial infarction; VEGF growth factor and sP-selectin increased significantly (p=0,002). E298D polymorphic NOS3 markers tended to increase (p=0,153).

The conclusion. A positive correlation was found between cytokines, immunoglobulins and adhesion molecules in patients with acute myocardial infarction, which confirms the effect of immune inflammation on endothelial dysfunction and thrombus formation in patients with myocardial infarction.

Key words: acute myocardial infarction, cytokines, chemokines, adhesion molecules.

(For citation: Sadikova R.I., Mutalova E.G. Effect of the cytokine network and role of intercellular adhesion molecules in endothelial dysfunction development in patients with acute myocardial infarction. Practical Medicine. 2018.)

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