Effect of the cytokine network and role of intercellular adhesion molecules in endothelial dysfunction development in patients with acute myocardial infarction
R.I. SADIKOVA, E.G. MUTALOVA
Bashkir State Medical University, 3 Lenin Str., Ufa, Russian Federation, 450000
Sadikova R.I. — Assistant Lecturer of the Department of Hospital Therapy №1, tel. (347) 260-40-07, e-mail: [email protected], ORCID ID: 0000-0002-6653-9194
Mutalova E.G. — D. Sc. (medicine), Professor, Head of the Department of Hospital Therapy №1, tel. (347) 260-40-07, e-mail:[email protected], ORCID ID: 0000-0002-7454-9819
To study the effect of cytokine regulation on the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), monocyte-macrophage factors (VEGF, MCP-1), and intercellular adhesion molecules (sVCAM-1, sP-selectin) on endothelial dysfunction in persons with acute myocardial infarction.
Material and methods. Patients with acute myocardial infarction were examined. Along with anamnesis, a clinical examination was conducted. Immunoenzymes (VEGF, MCP-1), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), molecular adhesion level (sVCAM-1, sP-selectin) were studied; analysis of association of the polymorphic locus of the enzyme that controls the content of NO (NOS3) was conducted.
Results. The level of pro-inflammatory cytokines reliably increased (p<0,05) in patients with acute myocardial infarction; VEGF growth factor and sP-selectin increased significantly (p=0,002). E298D polymorphic NOS3 markers tended to increase (p=0,153).
The conclusion. A positive correlation was found between cytokines, immunoglobulins and adhesion molecules in patients with acute myocardial infarction, which confirms the effect of immune inflammation on endothelial dysfunction and thrombus formation in patients with myocardial infarction.
Key words: acute myocardial infarction, cytokines, chemokines, adhesion molecules.
(For citation: Sadikova R.I., Mutalova E.G. Effect of the cytokine network and role of intercellular adhesion molecules in endothelial dysfunction development in patients with acute myocardial infarction. Practical Medicine. 2018.)
REFERENCES
- Shalʹnova S.A. et al. Epidemiological monitoring as a tool for planning programs for the prevention of chronic noncommunicable diseases and their risk factors. Profilakticheskaya meditsina, 2012, vol. 15, no. 6, pp. 64–68 (in Russ.).
- Jaeger C. et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. American heart journal, 2016, vol. 171, no. 1, pp. 92–102.
- Boytsov S.A. et al. Comparative analysis of data from Russian and foreign registers of acute coronary syndrome. Kardiologicheskiy vestnik, 2010, vol. 1, pp. 82–86.
- Milyutina O.V., Chicherina E.N. The prognostic role of the C-reactive protein in the development of the risk of cardiac events. Rossiyskiy kardiologicheskiy zhurnal, 2011, no. 1, pp. 71–73 (in Russ.).
- Mezhirova N.M., Danilova V.V., Ovcharenko S.S. Pathophysiological and diagnostic aspects of the systemic inflammatory response syndrome. Meditsina neotlozhnykh sostoyaniy, 2011, no. 1–2 (32–33) (in Russ.).
- Aronov D.M., Lupanov V.P. Some aspects of the pathogenesis of atherosclerosis. Ateroskleroz i dislipidemii, 2011, no. 1, pp. 48–56 (in Russ.).
- Mancini G.B.J. et al. Canadian Cardiovascular Society guidelines for the diagnosis and management of stable ischemic heart disease. Canadian Journal of Cardiology, 2014, vol. 30, no. 8, pp. 837–849.
- Henderson R.A. Acute coronary syndrome: optimising management through risk assessment. Clinical Medicine, 2013, vol. 13, no. 6, pp. 602–606.
- Arkhipova S.V. et al. Cytokines in myocardial infarction. Immunologiya, 2009, vol. 30, no. 2, pp. 104–107.
- Kachkovskiy M.A. et al. Assessing the effect of the intensity of the systemic inflammatory response on the size of myocardial necrosis according to a morphometric study. Morfologicheskie vedomosti, 2013, no. 3, pp. 53–56 (in Russ.).
- Libby P. Inflammation in atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 2012, vol. 32, no. 9, pp. 2045–2051.
- Mahalle N. et al. Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease. Annals of medical and health sciences research, 2014, vol. 4, no. 5, pp. 706–712.
- Ulumbekova E.G., Chelysheva Yu.A. Gistologiya, ehmbriologiya, tsitologiya: uchebnik dlya vuzov. 3-e izd. [Histology, embryology, cytology: a textbook for universities. 3rd ed.], 2009. 480 p.
- Gusev D.E. et al. Adhesion molecules sVCAM-1 and siCAM-1 in various forms of ischemic heart disease. Ishemicheskaya boleznʹ serdtsa, 2009, no. 2, pp. 11–14 (in Russ.).
- de Lemos J.A. et al. Serial Measurement of Monocyte Chemoattractant Protein-1 After Acute Coronary Syndromes Results From the A to Z Trial. Journal of the American College of Cardiology, 2007, vol. 50, no. 22, pp. 2117–2124.
- Konopka A. et al. Concentration of vascular endothelial growth factor in patients with acute coronary syndrome. Cytokine, 2013, vol. 61, no. 2, pp. 664–669.
- Gardner A.W. et al. Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease. Angiology, 2014, vol. 65, no. 8, pp. 683–690.
- Niu J., Kolattukudy P.E. Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. Clinical science, 2009, vol. 117, no. 3, pp. 95–109.
- Carlos T.M., Harlan J.M. Leukocyte-endothelial adhesion molecules. Blood, 1994, vol. 84, no. 7, pp. 2068–2101.
- Blankenberg S., Barbaux S., Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis, 2003, vol. 170, no. 2, pp. 191–203.
- Jin C. et al. Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation. Coronary artery disease, 2010, vol. 21, no. 5, pp. 273–277.
- Burger P.C., Wagner D.D. Platelet P-selectin facilitates atherosclerotic lesion development. Blood, 2003, vol. 101, no. 7, pp. 2661–2666.