V.V. MALEEV¹, E.N. LAZAREVA¹, M.M. HOK ², V.V. MAKASHOVA¹, O.S. ASTRINA¹, Kh.M. GALIMZYANOV², M.A. BABAEVA³

¹ Central Research Institute of Epidemiology of Rospotrebnadzor, 3 Novogireevskaya Str., Moscow, Russian Federation, 111123

² Astrakhan State Medical Institute of the Ministry of Health of Russia, Astrakhan, 123 Bakinskaya Str., Russian Federation, 414000

³ Regional Infectious Clinical Hospital named after A.M. Nichogi, Astrakhan, 7 Nachalovskoe highway, Russian Federation, 414000

Maleev V.V. — Academician of the Russian Academy of Sciences, D. Sc. (medicine), Professor, laureate of state prize and prize winner of the Government of the Russian Federation in the field of science and technology, Adviser to the Director of Scientific Work, tel. (495) 974-96-46, e-mail: maleyev@pcr.ru, wos – id – R-9793-2016

Lazareva E.N. — D. Sc. (medicine), Research Associate, e-mail: elniklazareva@yandex.ru, ORCID ID: 0000-0002-6081-1740

Hok M.M. — assistant of the Department of Infectious Diseases, е-mail: hokmarina@mail.ru

Makashova V.V. — D. Sc. (medicine), Professor, Leading Research Associate, e-mail: veramakashova@yandex.ru, ORCID ID: 0000-0002-0982-3527

Astrina O.S. — Ph. D. (Biology), Research Associate, tel. +7 (495) 974-96-46. e-mail: o.astrina@mail.ru, ORCID ID: 0000-0002-3820-2586

Galimzyanov Kh.M. — D. Sc. (medicine), Professor, Head of the Department, tel. (8512) 52-41-43, e-mail: agma@astranet.ru

Babaeva M.A. — Head, tel. (8512) 31-05-45, e-mail: babaeva_m_a@mail.ru

To determine the value of the functional activity of platelets and neutrophils, depending on their antioxidant potential in coxiellosis.

Material and methods. In 118 patients with coxiellosis, platelet aggregation and neutrophil aggregation were investigated.

Results. In 15,2% of patients, clinical manifestations of hemorrhagic syndrome were recorded, while against the background of thrombocytopenia, a decrease in the degree of platelet aggregation was noted 4 times, and of neutrophils – 2 times excess. Neutralization of lipid peroxidation products decreased due to depression of catalase (CT) in platelets by 3 times and in neutrophils – by 1,5 times.

The conclusion. Circulating C. burnetii strains in the Astrakhan Region in patients cause an imbalance in the relation of platelets and neutrophils, due to a decrease in CT activity in these blood cells.

Key words: coxiellosis, neutrophils, oxidative stress, platelets.

(For citation: Maleev V.V., Lazareva E.N., Hok M.M., Makashova V.V., Astrina O.S., Galimzyanov Kh. M., Babaeva M.A. Effect of oxidative stress on the functional activity of leukocytes and platelets in patients with coxiellosis. Practical Medicine. — 2018.)

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