M.M. VALIEVA¹, O.V. NESTEROV¹, E.V. URAKOVA¹, R.V. LEKSIN², R.Yu. ILYINA¹, I.R. KASHAPOV²

 ¹Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012

²Republic Clinical Hospital, 138A Orenburgskiy trakt, Kazan, Russian Federation, 420139

 Valieva M.M. — postgraduated student of the Department of Maxillofacial Surgery and Surgical Dentistry, tel.: (843) 554 54 25, e-mail: mari-aleeva@yandex.ru

Nesterov O.V. — PhD (medicine), Associate Professor, Head of the Department of Maxillofacial Surgery and Surgical Dentistry, e-mail: oleglena777@gmail.com, ORCID ID: 0000-0002-3298-1224

Urakova E.V. — PhD (medicine), Associate Professor of the Department of Maxillofacial Surgery and Surgical Dentistry, tel.: (843) 231-21-10, e-mail: anvu@rambler.ru, ORCID ID: 0000-0003-1140-6412

Leksin R.V. — Head of the Department of Maxillofacial Surgery, tel. (843) 231-21-10, e-mail: romanleksin75@gmail.com

Ilyina R.Yu. — PhD (medicine), Associate Professor of the Department of Maxillofacial Surgery and Surgical Dentistry, e-mail: ilroza@yandex.ru, ORCID ID: 0000-0001-8534-1282

Kashapov I.R. — maxillofacial surgeon, e-mail: ilnur_rinatovich@mail.ru

  The article presents the research of 54 patients with bisphosphonate-related osteonecrosis of a jaw. The results of special diagnostic methods (osteoscintigraphy and angiotensometry) are demonstrated. These methods are proposed as additional research methods of bisphosphonate-related osteonecrosis of jaws.

Key words: bisphosphonates, osteomyelitis, osteonecrosis, maxilla, mandibule, osteoscintigraphy, angiotensometry.

(For citation: Valieva M.M., Nesterov O.V., Urakova E.V., Leksin R.V., Ilyina R.Yu., Kashapov I.R. Early diagnosis of bisphosphonate-related osteonecroses of a jaw. Practical Medicine. 2018)

REFERENCES

1. Zaslavskaya N.A. Optimizatsiya profilaktiki i lecheniya bisfosfonatnykh osteonekrozov chelyustey u bolʹnykh so zlokachestvennymi novoobrazovaniyami: dis. … kand. med. nauk [Optimization of prevention and treatment of bisphosphonate osteonecrosis of the jaws in patients with malignant tumors. Dis. PhD med. sciences]. Moscow, 2014. 166 p.
2. Gelʹtser B.I., Zhilkova N.N., Anufrieva N.D., Kochetkova E.A. Bone lesions in multiple myeloma. Tikhookeanskiy meditsinskiy zhurnal, 2011, no. 3, pp. 11–15 (in Russ.).
3. Oral Complications Of Cancer And Its Management Sciubba J., Epstein J. Bisphosphonate-related osteonecrosis of the jaw. Oxford University Press, 2010, pp. 151–162.
4. Fleisher K.E., Garrett Welch, Shailesh Kottal et al. Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod, 2010, vol. 110, no. 4, rr. 509–516.
5. Sostoyanie onkologicheskoy pomoshchi naseleniyu Rossii v 2016 godu, pod red. A.D. Kaprina, V.V. Starinskogo, G.V. Petrovoy [The state of cancer care to the population of Russia in 2016. Ed. by A.D. Kaprin, V.V. Starinsky, G.V. Petrova]. Moscow: MNIOI im. P.A. Gertsena — filial FGBU “NMIRTS” Minzdrava Rossii, 2017. ill. 236 p.
6. Transillyuminatsionnaya kompressionnaya angiotenzometriya chelyustno-litsevoy oblasti v klinicheskoy praktike: ucheb.-metod. rekomendatsii [Transillumination compression angiotensometry of the maxillofacial area in clinical practice: proc. method. recommendations]. Kazan: Meditsina, 1995. 16 p.
7. Anikin S.G., Toroptsova N.V. Bisphosphonates: what we know about the undesirable effects associated with their use. FARMATEKA dlya praktikuyushchikh vrachey, 2012, no. 19, pp. 81–87 (in Russ.).
8. Ilʹinykh E.V., Barskova V.G., Lidov P.I., Nasonov E.L. Osteonecrosis. Part 1. Risk factors and pathogenesis. Sovremennaya revmatologiya, 2013, no. 1, pp. 17–23 (in Russ.).