T.E. KURMANBAYEV¹, N.V. YAKOVLEV^1,2, A.A. KHASANOV¹, I.G. MUSTAFIN¹, R.M. NABIULLINA¹

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012²Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

Kurmanbayev T.E. ― postgraduate student of the Department of Obstetrics and Gynecology №1, tel. +7-919-623-23-35, e-mail: timka_rus@inbox.ru

Yakovlev N.V. ― Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology №1, physician of Prenatal Center, tel. +7-903-307-55-02, e-mail: nkt.yakovlev@gmail Khasanov A.A. ― D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology №1, tel. (843) 236-08-73, e-mail: albirkhasanov@mail.ru

Mustafin I.G. ― D. Med. Sc., Professor, Head of the Department of Biochemistry and Clinical Laboratory Services, tel. +7-919-624-96-24, e-mail: sc-prorector@kgmu.kcn.ru

Nabiullina R.M. ― Cand. Med. Sc., Assistant of the Department of Biochemistry and Clinical Laboratory Services, tel. +7-917-898-72-50, e-mail: nabiullina.rosa@yandex.ru

 The article describes the coagulation stage of hemostasis by trombodynamic method in 66 pregnant and postpartum women without preeclampsia, with surgical delivery due to obstetric indications and/or extragenital pathology (n=32), and in pregnant and postpartum women with preeclampsia of varying degrees of severity, with surgical delivery (n=34). In both groups the hypercoagulation state was indicated, which in pre-eclampsia group was much more pronounced and slowly came to the normal condition , especially in postpartum women with severe preeclampsia. Also the prognostic significance of tromboyinamic method was shown in case of increase of the severity preeclampsia; the most informative parameters of this method were highlighted.

Key words: pregnancy, hypercoagulation, preeclampsia, trombodynamics.

REFERENCES

1. Barkagan Z.S., Momot A.P. Diagnostika i kontroliruemaya terapiya narusheniy gemostaza [Diagnosis and controlled therapy of hemostasis disorders]. Moscow: N’yudiamed, 2008. 292 p.
2. Zubairov D.M. Modern evidence of the concept of continuous blood clotting in the body. Tromboz, gemostaz i reologiya, 2010, no. 1, pp. 17-21 (in Russ.).
3. Makatsariya A.D., Bitsadze V.O., Smirnova L.M. et al. Trombogemorragicheskie oslozhneniya v akushersko-ginekologicheskoy praktike: rukovodstvo dlya vrachey [Thrombohemorrhagic complications in obstetric-gynecological practice: a guide for physicians]. Moscow, 2011. 1056 p.
4. Ramsay M. Normal hematological changes during pregnancy and the puerperium. J. New York Cambridge University Press, 2010, no. 7, pp. 3-12.
5. Momot A.P., Molchanova I.V., Batrak T.A. et al. Reference values ​​of indices of the system of hemostasis during physiologically occurring pregnancy and after delivery. Problemy reproduktsii, 2015, no. 1, pp. 89-97 (in Russ.).
6. Morikawa M., Yamada T., Akaishi R. et al. Changes in D-dimer levels after cesarean section in women with singleton and twin pregnancies. J. Thromb. Res, 2011, no. 9, pp. 59-66.
7. Oganesyan N.A., But-Gusaim L.S., Yurkevich S.V. Refferent values ​​of D-dimer in pregnant women and puerperas. Tromboz, gemostaz i reologiya, 2011, no. 3 (47), pp. 55-65 (in Russ.).