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  • Difficulties of clinical diagnosis of Conn’s syndrome (on the 65th anniversary of description)

    Редактор | 2020, Clinical case, Practical medicine part 18 №4. 2020 | 28 сентября, 2020

    S.N. IVANOVA1, 2 , O.A. SHORINA1, YU.E. SCHKERSKIYI2, N.A. SCHKERSKAYA2

     1 Northern State Medical University, Arkhangelsk

    2 Arkhangelsk Regional Clinical Hospital, Arkhangelsk

     Contact details:

    Ivanova S.N. — Ph. D. (medicine), Associate Professor of the Department of Hospital Therapy end Endocrinology, therapist

    Address: 51 Troitsky prospekt, Russian Federation, Arkhangelsk, 163000, tel.: +7 (8182) 632-996, e-mail: [email protected]

    The purpose — to present data on diagnosting the primary hyperaldosteronism due to an adrenal tumor, first described by Jerome Conn in November 1955.

    Material and methods. Conn’s syndrome includes arterial hypertension, muscle paralysis, and renal manifestations against the background of hypokalemia. A description of two clinical observations with different debuts of primary hyperaldosteronism (potassium penic kidney and hypokalemic paralysis) is presented. Timely diagnosis and operative treatment to remove an adrenal tumor in patients allowed stopping the disease clinical manifestations.

    Conclusion. The article is of interest to practitioners, as Conn’s syndrome debuted with hemorrhagic stroke and myasthenia gravis in combination with arterial hypertension and hypokalemia.

    Key words: primary hyperaldosteronism, Conn’s syndrome, aldosteroma, arterial hypertension, hypokalemia, potassium penic kidney, hypokalemic paralysis.

    REFERENCES

    1. Vetshev P.S., Podzolkov V.I., Rodionov A.V. et al. Primary hyperaldosteronism: to the 50th anniversary of the description of Conn’s syndrome. Problemy endokrinologii, 2004, vol. 50, no. 6, pp. 18–26 (in Russ.).
    2. Chernov K.P. Find a good umbrella and stand under it. Arterial’naya gipertenziya, 2008, vol. 14, no. 3, pp. 296–297 (in Russ.).
    3. Kalyagin A.N., Beloborodov V.A., Maksikova T.M. Symptomatic arterial hypertension against the background of primary hyperaldosteronism. Arterial’naya gipertenziya, 2017, vol. 23, no. 3, pp. 224–230 (in Russ.).
    4. Dutta R.K., Soderkvist P., Gimm O. Geneticsof primary hyperaldosteronism. Endocr. Relat Cancer, 2016, vol. 23 (10), pp. 437–454.
    5. Molashenko N.V., Troshina E.A. Primary idiopathic hyperaldosteronism in clinical practice. Ozhirenie i metabolizm, 2012, no. 4, pp. 3–9 (in Russ.).
    6. Protashchik D.V., Vorokhobina N.V., Shafigullina Z.R. et al. Clinical features of primary hyperaldosteronism. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. Mechnikova, 2013, vol. 5, no. 4, pp. 113–118 (in Russ.).
    7. Kiseleva E.R., Nashatyreva M.S., Fedotova V.N. et al. Primary hyperaldosteronism in therapeutic practice. Sibirskiy meditsinskiy zhurnal, 2016, no. 5, pp. 41–44 (in Russ.).

    Метки: 2020, aldosteroma, Arterial hypertension, Conn’s syndrome, hypokalemia, hypokalemic paralysis, N.A. SCHKERSKAYA, O.A. SHORINA, potassium penic kidney, Practical medicine part 18 №4. 2020, primary hyperaldosteronism, S.N. IVANOVA, YU.E. SCHKERSKIYI

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