Diagnostics and treatment of retinoblastoma
Z.S. ISLAMOV, R.Kh. USMANOV, M.S. GILDIEVA
Republican Oncology Scientific Center of Ministry of Healthcare of Uzbekistan Republic, 383 Faraby Str., Tashkent, Republic of Uzbekistan, 100174
Islamov Z.S. — Cand. Med. Sc., Head of the Department of Onco-Ophthalmology, tel. (+99871) 246-98-86, e-mail: dr_islamov@yahoo.com
Usmanov R.Kh. — Junior Researcher of the Department of Onco-Ophthalmology, tel. (+99871) 246-98-86, e-mail: r_usmanov77@mail.ru
Gildieva M.S. — D. Med. Sc., Head of the Laboratory of Tumors Genetics, tel. (+99871) 246-98-74, e-mail: galice@mail.ru
The article presents the results of the survey of 73 patients with retinoblastoma. Retinoblastoma is a rare intraocular malignant tumor of neuroectodermal origin, developing from immature retinal cells. It occurs mainly in children from birth to 5 years (90%). The analysis of the study results showed that 70% of patients were enrolled at advanced stages of tumor growth, and in 51 cases enucleation of the eyeball was performed. The modern diagnostic methods and organ-saving treatment allowed to preserve the eyeball in 30% of patients.
Key words: retinoblastoma, ultrasound investigation, enucleation, chemotherapy.
REFERENCES
- Saakyan S.V., Ivanova O.A. Analiz zabolevaemosti i effektivnosti lecheniya retinoblastomy [An analysis of the incidence and effectiveness of treatment of retinoblastoma]. Sovremennye tekhnologii v differentsial’noy diagnostike i lechenii vnutriglaznykh opukholey: Sbornik nauchnykh trudov Vserossiyskoy nauchno-prakticheskoy konferentsii. Moscow, 2007. Pp. 202-207.
- Abramson D.H. Retinoblastoma in the 20th century. Invest Ophthalmol Vis Sci., 2005, Aug., vol. 46 (8), rr. 2683-91.
- Brovkina A.F. The modern concept of treatment of retinoblastoma. Vestnik oftal’mologii, 2005, vol. 121, no. 2, pp. 48-51 (in Russ.).
- Broaddus E. et al. Incidence of retinoblastoma in the United States: 1975-2004. Br. J Ophthalmol., 2009, vol. 93, rr. 21-23.
- Neto De Aguirre J.C., Antoneli C.B., Ribeiro K.B. et al. Retinoblastoma in children older than 5 years of age. Ped. Blood Cancer, 2007, vol. 48 (3), rr. 292-5.
- Tero Kivelä. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br. J. Ophthalmol., 2009, vol. 93, rr. 1129-1131.
- Likhvantseva V.T., Kosheleva I.I., Kharlap S.I. Rol’ i mesto sovremennykh u.z. metodov diagnostiki v oftal’moonkologii [The role and place of modern UZ diagnostic methods in oftalmoonkologii]. Sovremennye metody luchevoy diagnostiki. Mat. n.-pr. konf. Moscow, 2004. Pp. 89-93.
- Nasnikova I.Yu., Kharlap S.P., Kruglova E.V. Prostranstvennaya ul’trazvukovaya diagnostika zabolevaniy glaza i orbity: Klinicheskoe rukovodstvo [Spatial ultrasonic diagnosis of diseases of the eye and orbit: clinical guidelines]. Moscow: Izd-vo RAMN, 2004. P. 176.
- Tatskov R.A., Saakyan S.V. Vozmozhnosti detskoy pediatricheskoy kamery (Ret Cam) v ranney v ranney diagnostike i monitoringe retinoblastomy [Features children’s pediatric camera (Ret Cam) early in the early diagnosis and monitoring of retinoblastoma]. Sovremennye tekhnologii v differentsial’noy diagnostike i lechenii vnutriglaznykh opukholey: Sb. nauchnykh trudov Vserossiyskoy nauchno-prakticheskoy konferentsii. Moscow, 2007. Pp. 127-131.
- Ushakova T.L., Maksimova O.V. et al. Rezul’taty lecheniya retinoblastomy standartnogo i srednego riska [The results of treatment of retinoblastoma and the standard average risk]. Sovremennye tekhnologii v differentsial’noy diagnostike i lechenii vnutriglaznykh opukholey: Sb. nauchnykh trudov Vserossiyskoy nauchno-prakticheskoy konferentsii. Moscow, 2007. Pp. 263-266.
- Imhof S.M., Moll A.C. et al. Extended reports, Stage of presentation and visual outcome of patients screened for familial retinoblastoma: nationwide registration in the Netherlands. Br J Ophthalmol., 2006, vol. 90, rr. 875-878. http://bjo.bmj.com/content/90/7/875.full – aff-1#aff-1, http://bjo.bmj.com/content/90/7/875.full — aff-1#aff-1
- Kaneko A., Suzuki Jpn.Sh. Eye-Preservation Treatment of Retinoblastoma with Vitreous Seeding. J. Clin. Oncol., 2003, vol. 33, no. 12, rr. 601-607.
- Knudson A.G. Mutation and cancer: a statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 1971, vol. 68, pp. 820-823.
- Murray T.G., Abramson D.H. et al. Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival. Pediatrics, 2003, rr. 112-1248.
- Moll A.C. et al. Extended reports, Stage of presentation and visual outcome of patients screened for familial retinoblastoma: nationwide registration in the Netherlands. Br J Ophthalmol., 2006, vol. 90, rr. 875-878.
- Vogel F. The genetics of retinoblastoma. Hum. Genet., 1979, vol. 52, pp. 1-54.