E.V. ULYANINA, N.R. AKHMADEEV

Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

  Ulyanina E.V. ― postgraduate student of the Department of Obstetrics and Gynecology named after prof. V.S. Gruzdev, e-mail: [email protected], ORCID ID: 0000-0002-2256-0856

Akhmadeev N.R. ― Cand. Med. Sc., Assistant of the Department of Obstetrics and Gynecology named after prof. V.S. Gruzdev, e-mail: [email protected], ORCID ID: 0000-0003-0908-7256

 Aim ― to determine the diagnostic value of vascular endothelial growth factor (VEGF) for improvement of perinatal outcomes in case of intrauterine growth restriction.

Material and methods. 50 paired women at their terms of gestation 22⁺⁰ – 39⁺⁰ weeks were examined. They were divided into subgroups: the I subgroup ― 22⁺⁰ – 29⁺⁶ weeks, the II subgroup ― 30⁺⁰ – 39⁺⁰ weeks. The examination included clinical anamnestic study, cardiotocography, the Doppler velocimetry and ultrasonography in the mother-placenta-fetus system with a predictive assessment of fetus growth, determination of a VEGF level in mother’s blood serum by enzyme-linked immunoassay.

Results. In the I subgroup of the research, a predictively significant criteria concerning implementation of antenatal death of a fetus, and early neonatal mortality is the VEGF level ≥ 200 pg/ml. In the II subgroup the VEGF level ≥ 130 pg/ml is defined as a predictor of development of asphyxia of an average degree and cerebral ischemia. In predicting the newborn’s need for hardware ventilation and transfer to the intensive care unit, as well as for the risk of developing intraventricular hemorrhage, the detected VEGF level ≥ 200 pg/ml is the optimal diagnostic method. Determination of the VEGF level had a great diagnostic value, in comparison with ultrasonic data and results of cardiotocography.

Conclusions. The present study has determined the predictive value of the VEGF level as a credible method in diagnosis of risk of intrauterine fetal death and fetal death during the early neonatal period.

Key words: Intrauterine Growth Restriction (IUGR), vascular endothelial growth factor, Doppler velocimetry.

(For citation: Ulyanina E.V., Akhmadeev N.R. Diagnostic value of vascular endothelial growth factor for intrauterine growth restriction. Practical Medicine. 2018)

REFERENCES

1. Unterscheider J., O’ Donoghue Keelin, Malone F.D. Guidelines of fetal growth restriction: A comparison of recent national publications. American Journal Perinatology, 2015, 32 (4), pp. 307-315.
2. Ganichkina M.B., Mantrova D.A., Kan N.E. Conducting pregnancy with fetal growth retardation. Akusherstvo i ginekologiya, 2017, no. 10, pp. 5-10 (in Russ.).
3. Artyunyan I.V., Kananykhina E.Yu., Makarov A.V. The role of VEGF-A165 receptors in angiogenesis. Kletochnaya transplantologiya i tkanevaya inzheneriya, 2013, vol. 8, no. 1, pp. 12-18 (in Russ.).
4. Lascowska M., Lascowska K., Oleszczuk J. aVEGF-A and its soluble receptor type-1 (sVEGFR-1, sFlt-1) concentracions in pregnancies with intrauterine growth restriction in the presence or absence of preeclampsia. Research. Journal of Pharmaceutical, Biological and Chemical, 2015, 6 (2), pp. 319-325.
5. Yakovleva N.Yu., Vasilʹeva E.Yu., Shelepova E.S. Study of the dynamics of concentrations of angiogenesis factors during physiological pregnancy. Akusherstvo i ginekologiya, 2016, no. 8, pp. 49-53 (in Russ.).
6. Strizhikov A.N., Timokhina T.F., Baev O.R. Placental insufficiency: pathogenesis, diagnosis, treatment. Voprosy ginekologii, akusherstva i perinatologii, 2003, vol. 2, no. 2, pp. 53-64 (in Russ.).
7. Emily J., Hong X., Matthew D. et al. Impaired fetoplacental angiogenesis in growth restriction fetuses with abnormal umbilical artery Doppler velocymetry is mediated by aryl hydrocarbon receptor nuclear translocator. Clin. Endocrin. Metab, 2015, 100 (1), pp. 30-40.