D.S. SARKSYAN¹, O.V. MALININ¹, M.V. DUDAREV¹, L.I. KHALITOVA¹, V.G. IVANOV¹, G.M. IVANOVA¹^—², N.I. BULATOVA² 

¹Izhevsk State Medical Academy, 281 Communarov St., Izhevsk, Russian Federation, 426000

²2^nd Republican Clinical Hospital 230 Svobody St., Izhevsk, Russian Federation, 426000

Sarksyan D.S. — Cand. Med. Sc., Associate Professor of the Department of Infectious Diseases and Epidemiology, tel. +7-904-310-64-14, e-mail: bizi1973@gmail.com¹

Malinin O.V. — Cand. Med. Sc., Associate Professor, Head of the Department of Infectious Diseases and Epidemiology, tel. +7-912-762-90-89, e-mail: oleg.malinin@yahoo.com¹

Dudarev M.V. — D. Med. Sc., Associate Professor, Head of the Department of Outpatient Therapy, tel. +7-912-767-28-33, e-mail: flatly@yandex.ru¹

Khalitova L.I. — postgraduate student of the Department of Outpatient Therapy, tel. +7-912-455-84-60, e-mail: halitova-lilya@rambler.ru¹

Ivanov V.G. — Cand. Med. Sc., Associate Professor of the Department of Clinical Biochemistry, tel+7-906-819-88-08, e-mail: vitahelp@mail.ru¹

Ivanova G.G. — Cand. Med. Sc., Assistant Lecturer of the Department of Clinical Biochemistry, tel. +7-906-819-88-08, e-mail: vitahelp@mail.ru^1,2

Bulatova N.I. — laboratory doctor, tel. (3412) 78-37-43²

The content of cystatin C in serum in Ixodidea tick borreliosis caused B. miyamotoi was studied. To confirm the specific diagnosis, PCR technique was used. The patients were divided into 2 groups by the presence of clinical-laboratory signs of renal pathology. For each group a number of indicators were evaluated characterizing the filtration and concentration functions of kidney. The correlation of these parameters with the content of cystatin C serum was studied. It was shown that serum cystatin C is a more sensitive marker of glomerular dysfunction than urea and creatinine levels in a single study.

Key words: Ixodidea tick borreliosis, Borrelia miyamotoi, clinical pattern, renal lesions, serum cystatin C.

REFERENCES

1. Conti M., Moutereau S., Zater M. et al. Urinary cystatin C as a specific marker of tubular dysfunction. Clin. Chem. Lab. Med., 2006, vol. 44 (3), pp. 288-291.

2. Shlipak M.G. Cystatin C: research priorities targeted to clinical decision making. Am. J. Kidney Dis., 2008, vol. 51, pp. 358-361.

3. Platonov A.E., Karan L.S., Kolyasnikova N.M. et al. Humans infected with the relapsing fever spirochete Borrelia miyamotoi, Russia. Emerg. Infect. Dis., 2011, vol. 17 (10), pp. 1816-1822.

4. Sarksyan D.S., Maleev V.V., Platonov A.E. et al. Clinical forms of the disease caused by Vorrelia myamotoi. Infektsionnye bolezni, 2013, no. 1 (suppl.), pp. 355-356 (in Russ.).

5. Sarksyan D.S., Maleev V.V., Platonov A.E. et al. Clinical and renal function in patients with Ixodes tick-borne Lyme disease, caused by B. miyamota. Infektsionnye bolezni, 2013, no. 11 (2), pp. 21-25 (in Russ.).

6. Platonov A.E, Sarksyan D.S, Karan L.S., Maleev V.V., Fish D., Krause P.J. Meta-analysis of the clinical presentation and epidemiological features of 128 Borrelia miyamotoi cases from Russia. Abstracts of 13th International Conference on Lyme Borreliosis and other Tick-Borne Diseases; Boston, August 17-21, 2013. R. 22.

7. Nefrologiya, rukovodstvo dlya vrachey, pod redaktsiey I.E. Tareevoy [Nephrology, a guide for physicians. Edited by I.E. Tareyeva]. Moscow: Meditsina, 2000.

8. Sarksyan D.S., Platonov A.E., Karan’ L.S. et al. Clinical features of the «new» borreliosis caused by Borrelia miyamota. Terapevticheskiy arkhiv, 2012, no. 11, pp. 38-46 (in Russ.).

9. Nazarenko G.I., Kishkun A.A. Laboratornye metody diagnostiki neotlozhnykh sostoyaniy [Laboratory methods for the diagnosis of emergency conditions]. Moscow: Meditsina, 2002.

10. Guo B.P., Teneberg S, Munch R. at al. Releapsing fever Borrelia binds to neolacto glicans and mediates resetting of human erythrocytes. Proc. Natl. Acad. Sci. USA, 2009, vol. 106 (46), rr. 280-285.

11. Hardy P. H. Jr., Level J. Lack of endotoxin in Borrelia hispanica and Treponema pallidum. Proc. Soc. Exp. Biol. (N.Y.), 1983, vol. 174 (1), rr. 47-52.