Cytoprotective correction of functional microcirculation and hemostatic disorders in spine-spinal cord injury
N.M. GRUBER, E.K. VALEYEV, R.G. KUZNETSOVA, G.G. YAFAROVA,
D.Z. MITYUKOVA, I.E. VALEYEV
Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064,
Gruber N.M. — PhD (Biology), Leading Researcher of the Research Department, tel. (843) 237-35-23, e-mail: rkb_nauka@rambler.ru
Valeyev E.K. — D. Med. Sc., Chief Researcher of Scientific-Research Department, tel. +7-987-296-88-52, e-mail: ekv44@mail.ru
Кuznetsova R.G. — Senior Researcher of the Research Department, tel. (843) 237-34-47, e-mail: rokuz@mail.ru
Yafarova G.G. — PhD (Medicine), Leading Researcher of Scientifc-Research Department, tel. (843) 237-35-23, e-mail: gusadila@mail.ru
Мityukova D.Z. — laboratory doctor of the Express-laboratory ORIT № 4, tel. (843) 237-35-23, e-mail: rkb_nauka@rambler.ru
Valeyev I.E. — PhD (Medicine), Head of the Department of Neurosurgery № 2, tel. +7-987-296-88-51, e-mail: ekv44@mail.ru
Experimental and clinical research of changes of the functional parameters of microcirculation and hemostatic disorders in spine-spinal cord injury is carried out. It is revealed that compression fracture of the body 1 of lumbar vertebra causes significant shifts in the studied systems as early as 30 minutes after injury: lowering of blood pressure and blood flow to vital organs, spasm and anemia of capillaries, opening of arterio-venous anastomoses, venous plethora, stasis, sludge of erythrocytes, etc. Inadequate blood flow entails hypoxia and activation of blood components coagulation with depression of fibrinolytic and anticoagulation links of plasma hemostasis. The combination of hemostatic disorders indicates the danger of ДВСsyndrome. For normalization and improvement of metabolism and prevention of irreversible disorders in vital systems, the drug gliatilin was applied. The introduction of this holinomimetics to intact animals does not cause pathological changes in the systems of microcirculation and hemostasis. When used for the correction of the above spine — spinal injuries, a slight activation of the coagulation of blood components was revealed with compensatory normalization of anticoagulant and fibrinolytic links of hemostasis. Gliatilin reduces the risk of thrombohemorrhagic complications and increases the survival rate of animals in posttraumatic period. The use of gliatilin in the clinic for treatment of patients with severe spine with spinal injuries in the complex treatment leads to regress of neurological symptoms and reduces the rehabilitation period of patients.
Key words: microcirculation, hemostasis, spine-spinal injury, gliatilin.
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