O.N. LEVANOVA¹, V.A. SOKOLOV¹, V.G. LIKHVANTSEVA², A.A. NIKIFOROV¹

¹Ryazan State Medical University named after I.P. Pavlov, 9 Vysokovoltnaya Str., Ryazan, Russian Federation, 390026

²Institute of Advanced Training of Federal Medical-Biological Agency of Russia, 91 Volokolamskoye shosse Str., Moscow, Russian Federation, 125371 

Levanova O.N. ― postgraduate student of the Department of Ocular and ENT Diseases, tel. +7-920-631-86-71, e-mail: Levanova.olga2013@yandex.ru

Sokolov V.A. ― D. Med. Sc., Professor of the Department of Ocular and ENT Diseases, tel. +7-903-835-53-07, е-mail: sva_sva@mail.ru

Likhvantseva V.G. ― D. Med. Sc., Professor of the Department of Ophthalmology, tel. +7-916-659-41-56, e-mail: likhvantseva-4@yandex.ru

Nikiforov A.A. ― Associate Professor of the Department of Pharmacology, Head of Central Scientific-Research Laboratory, tel. +7-920-970-25-03, e-mail: alnik003@yandex.ru

The article presents the results of a survey of 66 patients with primary open angle glaucoma (120 eyes) and 14 patients of the control group (28 eyes). Along with ophthalmic examination, the concentration of MMP-2 and MMP-9 in the lacrimal fluid in both eyes were determined with «sandwich» ELISA technique. The characteristic of clinical, functional and morphometric parameters of patients is given. The reference values are determined of the concentrations of MMP-2 and MMP-9 in tears of the control group and in patients with primary open-angle glaucoma. The direct coupled connection was revealed between MMP-2 and MMP-9 (the coefficient of correlation k=0,647, p<0.001). The correlation analysis of the levels of MMP-2 and MMP-9 with clinical, morphometric and functional indicators was performed. The results of the study indicate the relationship between the MMP-2 and MMP-9 production and confirm their possible involvement in the pathogenesis of POAG.

Key words: glaucoma, matrix metalloproteinases, lacrimal fluid.

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