Yu.E. NIKITIN, E.N. NIKITIN, A.E. SHKLYAEV

Izhevsk State Medical Academy, 281 Kommunarov St., Izhevsk, Russian Federation 426034

Nikitin Yu.E.— postgraduate student of the Department of Intermediate Level Therapy with the Courses of Endocrinology and Hematology, tel. (3412) 46-55-78, е-mail: [email protected]

Nikitin E.N. — D. Med. Sc., Professor of the Department of Intermediate Level Therapy with the Courses of Endocrinology and Hematology, tel. (3412) 46-85-36, е-mail: [email protected]

Shklyaev A.E. — D. Med. Sc., Professor of the Department of Intermediate Level Therapy with the Courses of Endocrinology and Hematology, tel. (3412) 46-55-78, e-mail: [email protected]

This article reports the results of determining the peptide hormone hepcidin in 64 patients with community-acquired pneumonia. The interaction between hepcidin and interleukine-6, —10, erythropoietin, indicators of iron metabolism and peripheral blood is explained. Is presented the role of hepcidin in pathogenesis of anemia in case of community-acquired pneumonia. New data were found concerning the influence of hepcidin on recovery of iron metabolism and level of hemoglobin on outcomes of community-acquired pneumonia.

Key words: community-acquired pneumonia, anemia, hepcidin, cytokines, iron metabolism.

REFERENCES

1. Krause A., Neitz S., Magert H. J. et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibit antimicrobial activity. FEBS Letters, 2000, vol. 480, no. 2, pp. 147-150.

2. Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem., 2001, vol. 276, no. 11, pp. 7806-7810.

3. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 2003, vol. 102, no. 3, pp. 783-788.

4. Nemeth E. Hepcidin: the principal regulator of systemic iron metabolism. Hematology (EHA Educ. Program), 2006, no. 2, pp. 36-41.

5. Levina A.A., Kazyukova T.V., Tsvetaeva N.V. et al. Hepcidin as a regulator of iron homeostasis. Pediatriya, 2008, vol. 87, no. 1, pp. 67-74 (in Russ.).

6. Pavlov A.D., Morshchakova E.F., Rumyantsev A.G. Eritropoez, eritropoetin, zhelezo [Erythropoiesis, erythropoietin and iron]. Moscow: GEOTAR-Media, 2011. 304 p.

7. Wrighting D.M., Andrews N.C. Interleukin-6 induces hepcidin expression through STAT 3. Blood, 2006, vol. 108, no. 9, pp. 3204-3209.

8. Peyssonnaux C., Zinkemagel A., Schuepbach R., Johnson R. Regulation of iron homeostasis by the hypoxia-inducible factors (HIFs). J. Clin. Invest., 2007, vol. 117, no. 7, pp. 1926-1932.

9. Yoon D., Pastore Y.D., Divoky V. et al. Hypoxia_inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse. J. Biol. Chem., 2006, vol. 281, no. 35, pp. 25703-25711.

10. Merle U. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology, 2007, vol. 148, no. 6, pp. 2663-2668.

11. Kim H.R., Kim K.W., Yoon S.Y. et al. Serum pro-hepcidin could reflect disease activity in patients with rheumatoid arthritis. J. Korean Med. Sci., 2010, vol. 25, no. 3, pp. 348-352.

12. Galushko E.A., Belen’kiy D.A., Aleksandrova E.N., Kashnikova L.N. The role of hepcidin in the development of anemia in patients with rheumatoid arthritis. Nauchno-prakticheskaya revmatologiya, 2012, vol. 52, no. 3, pp. 19-24 (in Russ.).

13. Nikiforovich I.I., Litvinov A.V., Ivanyan A.N. The role of hepcidin in the development of anemia in pregnant. Rossiyskiy vestnik akushera-ginekologa, 2010, no. 1, pp. 11-14 (in Russ.).

14. Chuchalin A.G., Sinopal’nikov A.I., Kozlov R.S. et al. Vnebol’nichnaya pnevmoniya u vzroslykh: prakticheskie rekomendatsii po diagnostike, lecheniyu i profilaktike: posobie dlya vrachey [Community-acquired pneumonia in adults: guidelines for diagnosis, treatment and prevention: A guide for physicians]. Moscow, 2010.

15. Simbirtseva A.S. Cytokines: classification and biological functions. Tsitokiny i vospalenie, 2004, vol. 3, no. 2, pp. 16-21 (in Russ.).

16. Mehr S., Doyle L. Cytokines as markers of bacterial sepsis in newborn infants: a review. Pediatr. Infect. Dis. J., 2007, no. 19, pp. 879-887.