G.R. ABRAMYAN

Republican Institute of Reproductive Health, Perinatology, Obstetrics and Gynecology of Armenia, 6/2 Markaryan Str., Yerevan, Armenia, 0078

Moscow First Medical University named after I.M. Sechenov, 2 Bolshaya Pirogovskaya Str., Moscow, Russian Federation, 119991

Abramyan G.R. — Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology No. 2, tel. (37410) 34-18-83, e-mail: rirhpog@gmail.com

With vast clinical material, the author substantiates the significance of pro-angiogenic and anti-angiogenic factors (PIGF and sFlt-1), as well as ratio of the latter, for prognosis of preeclampsia development (increase of ratio of sFlt-1 level to PlGF level), and, consequently, prognosis of the course and outcome of pregnancy. Also, analysis was carried out of the abovementioned factors in groups with spontaneous and “assisted” (after in vitro fertilization) pregnancies. The important role of these factors for IVF results forecasting was stated.

Key words: placental growth factor (PIGF), soluble variation of fms-like tyrosine kinase (sFlt-1), PIGF/sFlt-1, preeclampsia, in vitro fertilization (IVF).

References

1. Placental growth factor (PlGF) and sFlt-1 during pregnancy: physiology, assay and interest in preeclampsia. Lecarpentier É, et al. AnnBiolClin (Paris). 2016.Jun.1;74(3);259-267
2. Serum soluble fms-like tyrosine kinase-1 in the three trimesters of pregnancy: effects of maternal characteristics and medical history. Tsiakkas A. et al. UK, Ultrasound Obstet.Gynecol.2015 May 45(5)
3. First trimester serum angiogenic/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology. Sánchez O. etal.Spain,Hum.Reprod.2012:27(2).
4. Angiogenic markers in pregnancies conceived through in vitro fertilization. Lee M.S. Am J Obstet Gynecol. 2015. 213,212.e 1-8
5. Circulating Angiogenic Factors and the Risk of Preeclampsia. Levine R.J., Maynard S.E. et al. The New England Journal of 2004.Feb.
6. Angiogenic factors and preeclampsia. Maynard S.E., Karumanchi S.A. SeminNephrol. Jan.31(1):33-46
7. Molecular mechanisms of preeclampsia. Mutter W.P. Karumanchi S.A., Microvasc Res. 2008.Jan;75(1):1-8
8. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
9. Zeisler H et al. N Engl J Med. 2016;374;13-22 January 7
10. Diagnostic accuracy of the soluble Fms-like tyrosine kinase-1/placental growth factor ratio for preeclampsia: a meta-analysis based on 20 studies. Liu Y. et al. Arch Gynecol. Obstet. 2015.Sep.;292(3):507-18
11. Implementation of the sFlt-1/PLGD ratio for prediction and diagnosis of preeclampsia in in singleton pregnancy: implications for clinical practice. Stepan H. etal. Ultrasound Gynecol. 2015.Mar;45(3):241-6
12. Uterine artery Doppler and sFlt-1/PlGF ratio: prognostic value in early-onset preeclampsia. Gómez-Arriaga P. I. etal. Ultrasound Gynecol. 2014.
13. Multicenter prospective clinical study to evaluate the prediction of short-term outcome in pregnant women with suspected preeclampsia (PROGNOSIS): study protocol. Hund M. etal. BMC Pregnancy 2014.Sep.18;14:324
14. Chronic kidney disease may be differentially diagnosed from preeclampsia by serum biomarkers. Rolfo A. et al. Elsevier 2013, 177-181.
15. Angiogenic defects in preeclampsia: What is known, and how are such defects relevant to preeclampsia pathogenesis? Keizo Kanasaki, Megumi 2013.March 31