Clinical observation of the Stevens ― Johnson syndrome against the backdrop of severe pneumonia
O.I. GOLUBTSOVA1, N.P. ANDREEVA2, T.I. PETROVA2, L.A. GERASIMOVA1, I.A. SKVORTSOVA1, O.N. SERGEEVA1, L.A. KOTSURAK1, L.A. NIKOLAEVA2
1Republican Children’s Clinical Hospital of the Ministry of Health of the Chuvash Republic, 27 Gladkova Str., Cheboksary, Russian Federation, 428020
2Chuvash State University named after I.N. Ulyanov, 15 Moskovsky Ave., Cheboksary, Russian Federation, 428015
Golubtsova O.I. — Cand. Med. Sc., Head of the Department of Pulmonology and Allergology, tel. (8352) 55-02-53, e-mail: vakcina2007@mail.ru
Andreeva N.P. — Cand. Med. Sc., Associate Professor of the Department of Pediatrics and Pediatric Surgery, tel. (8352) 56-31-72, e-mail: NataliUTT@ya.ru
Petrova T.I. — D. Med. Sc., Professor of the Department of Pediatrics and Pediatric Surgery, tel. (8352) 56-31-72, e-mail: ptiprop@mail.ru
Gerasimova L.A. — pulmonologist of the Department of Pulmonology and Allergology, tel. (8352) 55-01-26, e-mail: rdkb@med.cap.ru
Skvortsova I.A. — allergist-immunologist of the Department of Pulmonology and Allergology, tel. (8352) 55-01-26, e-mail: rdkb@med.cap.ru
Sergeeva O.N. — allergist-immunologist, tel. (8352) 55-01-26, e-mail: rdkb@med.cap.ru
Kotsurak L.A. — pulmonologist of the Department of Pulmonology and Allergology, tel. (8352) 55-01-26, e-mail: rdkb@med.cap.ru
Nikolaeva L.A. — Assistant of the Department of Childhood Diseases, tel. (8352) 56-31-72, e-mail: doctornicolaeva@ya.ru
The article presents a clinical case of the Stevens ― Johnson syndrome formation on the background of the treatment of severe community-acquired pneumonia. The characteristic of anamnestic, clinical, laboratory data of the patient is given. The reasons for the formation of severe toxic-allergic reactions on the background of the treatment of community-acquired pneumonia are considered. The article presents treatment regimen that included an intense infusion, disintoxication, antibacterial therapy, anti-inflammatory local therapy, provision of a hypoallergenic diet. The observed case illustrates the possibility of developing a rare, in relation to other adverse reactions, complication of antibiotic therapy. The attention is paid to the existence of a low awareness of physicians with regard to etiopathogenesis and clinical symptoms of the rare manifestations of drug allergy.
Key words: community-acquired pneumonia, Stevens ― Johnson syndrome, allergy.
REFERENCES
1. Astaf’eva N.G., Goryachkina L.A. Drug allergies. Allergologiya, 2000, no. 3, pp. 31-40 (in Russ.).
2. Klinicheskie rekomendatsii. Allergologiya, pod red. R.M. Khaitova, N.I. Il’inoy [Clinical guidelines. Allergolog. Ed. by R.M. Haitova, N.I. Ilyina]. Moscow: GEOTAR-Media, 2006. 240 p.
3. Latysheva T.V., Myasnikova T.N. Features of acute toxic-allergic reactions to medicines in children. Voprosy gematologii, onkologii i immunopatologii v pediatrii, 2003, vol. 2, no. 3, pp. 60-64 (in Russ.).
4. Mel’nikova I.Yu., Shaytor V.M. Toxic-allergic dermatitis in children. Voprosy sovremennoy pediatrii, 2008, vol. 7, no. 4, pp. 68-74 (in Russ.).
5. Czubkowska I. Erythema multiforme in children versus Stevens — Johnson syndrome. Wiad. Lek, 2000, vol. 53, (1-2), pp. 43-48.
6. Wetter D.A., Davis M.D. Recurrent erythema multiforme: clinical characteristics, etiologic associations, and treatment in a series of 48 patients at Mayo Clinic, 2000 to 2007. J. Am. Acad. Dermatol, 2010, no. 62 (1), pp. 45-53.