L.F. GALIMOVA, E.P. SOLOVYOVA, N.N. KURCHATOVA

All-Russia Eye and Plastic Surgery Centre of the Russian Health Ministry, 67/1 Zorge Str., Ufa, Russian Federation, 450075 

Galimova L.F, Cand. Med. Sc., surgeon-ophthalmologist, tel. (437) 293-42-14, e-mail: lilia-galimova@mail.ru

Solovieva E.P, Cand. Med. Sc., pathologist of the Department of Morphology, tel. (437) 293-42-35, e-mail: dikatang@gmail.com

Kurchatova N.N, Cand. Med. Sc., Head of the Clinical Diagnostic Laboratory, tel. (437) 293-42-35

 22 clinical cases were studied of eyeball enucleation in patients with post-traumatic uveitis, which we diagnosed as sympathetic inflammation. Histopathological and immunological studies were carried out. 8 patients (36.4%) were diagnosed to have sympathetic inflammation. At risk of sympathetic ophthalmia were patients, who had undergone operations and repeated vitreoretinal interventions on the injured eyes, as well as patients with autoimmune disorders. The absence of cell and humoral sensibilization to S-antigen of the retina was explained by the local and systemic corticosteroid therapy for prevention of uveitis relapses. According to our research, the timely preventive enucleation of eyes with post-traumatic relapsing uveitis has interrupted the bilateral autoimmune process, which was limited to the injured eye.

Key words: sympathetic ophthalmia, sympathetic irritation, morphological investigation of the injured eye, preventive enucleation.

REFERENCES

1. Arkhipova L.T. Simpaticheskaya oftal’miya [Sympathetic ophthalmia]. Moscow: Moskva, 2006. 248 p.
2. Kulikova M.P. Pokazaniya k udaleniyu glaznogo yabloka posle pronikayushchikh raneniy glaz: avtoref. dis. … kand. med. nauk [Indications for removal of the eyeball after penetrating eye injuries. Synopsis of dis. PhD med. sciences]. Moscow, 1978.
3. Dolgova I.G. Kliniko-immunologicheskie i biokhimicheskie pokazateli v prognoze travmaticheskikh uveitov: avtoref. dis. … kand. med. nauk [Clinical and immunological and biochemical parameters in the prognosis of traumatic uveitis. Synopsis of dis. PhD med. sciences]. Moscow, 1999.
4. Liddy B.S., Stuart J. Sympathetic ophthalmia in Canada. Can. J. Ophthalmol, 1972, no. 7, pp. 157-159.
5. Marak G.E. Recent advances in sympathetic ophthalmia. Surv. Ophthalmol, 1979, vol. 24, no. 3, pp. 140-156.
6. Kilmartin D.J., Dick A.D., Forrester J.V. Sympathetic ophthalmia risk folloving vitreectomy: should we counsel patients? Brit. J. Ophthalmol, 2000, no. 84, pp. 448-449.
7. Khoroshilova-Maslova I.P., Arkhipova L.T., Shkvorchenko D.O. et al. Clinical and morphological study in 6 cases after penetrating trauma and subsequent repeated vitreoretinal operations. Vestnik oftal’mologii, 2005, no. 5, pp. 38-41 (in Russ.).
8. Vershigora A.E. Obshchaya immunologiya [General Immunology]. Kiev: Vyshcha shkola, 1990. 736 p.
9. Yarilin A.A. Osnovy immunologii [Fundamentals of Immunology]. Moscow: Meditsina, 1999. 608 p.
10. Galimova L.F., Kurchatova N.N., Stepanov M.V. et al. Evaluation of the overall immune status of patients with posttraumatic subatrophy eyes. Vestnik OGU, 2013, no. 4, pp. 51-54 (in Russ.).