Clinical importance and modern methodological aspects of determining the level of carboxy-and methaemoglobin in blood
K.V. PHATKULLIN1, A.Zh. GILMANOV1, D.V. KOSTYUKOV2
1Bashkir State Medical University, 3 Lenina St., Ufa, Russian Federation 450000
2Research and Production Enterprise TEKHNOMEDICA, P.O. Box 1, Moscow, Russian Federation 127081
Phatkullin K.V. — postgraduate student of the Department of laboratory diagnostics of Institute of Postgraduate Education, tel. +7-965-922-19-92, e-mail: kimf@mail.ru1
Gilmanov A.Zh. — D. Med. Sc., Professor, Head of the Department of laboratory diagnostics of Institute of Postgraduate Education, tel. +7-927-237-55-82, e-mail: alex_gilm@mail.ru1
Kostyukov D.V. — engineer, top specialist, tel. (495) 966-08-81, e-mail: tm@technomedica.com2
The article describes mechanisms of formation of carboxy-and methaemoglobin in the body, main reasons of the increased concentration in blood under pathological conditions (intoxication), pathogenesis, peculiarities of clinical presentation and diagnosis of a developing intoxication. Comparative characteristics of traditional and modern laboratory methods for determining the concentration of said derivatives of hemoglobin in the blood is given: principles, features, advantages and disadvantages are described.
Key words: carboxyhaemoglobin, methemoglobin, intoxication, laboratory methods.
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