I.V. MANNANOVA, O.N. KHPKHLOVA, Zh.B. PONEZHEVA

 Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Services, 3a Novogireyevskaya Str., Moscow, Russian Federation, 111123

 Mannanova I.V. — Junior Researcher of the Clinical Department of Infectious Pathology, e-mail: irinasemenova07@rambler.ru, ORCID 0000-0003-2244-8810

Khokhlova O.N. — Ph. D. (medicine), Researcher of the Clinical Department of Infectious Pathology and the specialized scientific-research Department of AIDS Epidemiology and Prevention, tel. +7 (495) 366-05-18, e-mail: x.olia79@mail.ru, ORCID 0000-0003-3069-5686

Ponezheva Zn.B. — D. Sc. (Medicine), Leading Researcher of the Clinical Department of Infectious Pathology, e-mail: doktorim@mail.ru, ORCID 0000-0002-6539-4878

To study the clinical and immunological features in patients with chronic hepatitis C, depending on the degree of liver fibrosis.

Material and methods. On the basis of the clinical department of infectious pathology of the Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Services, 45 patients with chronic hepatitis C were examined. A comparative study of indicators of immune status was conducted: total number of T-lymphocytes (CD3+CD19-), number of T-helpers (CD3+CD4+), number of cytotoxic T-helpers (CD3+CD8+), immunoregulatory index (CD3+CD4+/CD3+CD8+), number of cells expressing receptors for alpha and gamma interferons (CD118+, CD119+).

Results. The proportion of CD118+, CD119+ lymphocytes in patients with CHC was higher than that of healthy donors. When analyzing the enhanced immune status, the relative number of NK-T cells (CD45+CD3+CD16+CD56+) increased with the severity of fibrosis.

The conclusion. The fact of the correlation of the relative number of NKT cells and the level of lymphocytes expressing receptors for interferons – α/β (CD118+) is of interest in terms of the use of this indicator as a predictor of CHC progression.

Key words: chronic hepatitis C, liver fibrosis, CD118+ lymphocytes, CD119+ lymphocytes.

(For citation: Mannanova I.V., Khokhlova O.N., Ponezheva Zn.B. Clinical-immunological features of chronic hepatitis type C depending on the degree of liver fibrosis. Practical Medicine. 2018.)

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