A.A. BOGOV¹, А.R. GALLYAMOV^1-3, I.G. KHANNANOVA¹, G.A. MASGUTOVA², R.I. MULLIN¹, I.F. AKHTYAMOV^1,3, A.P.KIYASOV²

¹Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

²Kazan Federal University, 18 Kremlevskaya Str., Kazan, Russian Federation, 420008

³Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

Bogov A.A. ― D. Med. Sc., Professor, Head of the Traumatology Department №2, tel. (843) 237-34-25, e-mail: bogov_a@mail.ru

Gallyamov A.R. ― traumatologist-orthopeadist of the Traumatology Department №2, postgraduate student of the Department of Traumatology, Orthopeadics and Emergency Surgery, tel. (843) 237-34-25, e-mail: almaz.gallyamov@gmail.com

Khannanova I.G. ― Cand. Med. Sc., traumatologist-orthopeadist of the Traumatology Department №2, tel. (843) 237-34-25, e-mail: hannanovaig@gmail.com

Masgutova G.A. ― Cand. Biol. Sc., Senior Researcher, tel. (843) 237-34-25, e-mail: galina2526@gmail.com

Mullin R.I. ― Cand. Med. Sc., traumatologist-orthopeadist of the Traumatology Department №2, tel. (843) 237-34-25, e-mail: mullinri@gmail.com

Akhtyamov I.F. ― D. Med. Sc., Professor, Head of the Head of the Department of Traumatology, Orthopeadics and Emergency Surgery, Chief Researcher, tel. (843) 221-36-68, e-mail: yalta60@mail.ru

Kiyasov A.P. ― D. Med. Sc., Professor, Leading Researcher, tel. (843) 236-78-92, e-mail: APKiyasov@kpfu.ru

The review presents the basic principles of surgical treatments of peripheral nerve injuries and the effects of auto-cells of the stromal vascular fraction on nerve tissue. The carried out experiments on the issue are described. The results of treatment with auto-cells of the stromal vascular fraction are summarized.

Key words: peripheral nerve injury, stem cells of the stromal vascular fraction.

REFERENCES

1. Bersnev V.P. et al. Evaluation of the results of surgical treatment of injuries of the sciatic nerve. Travmatologiya i ortopediya Rossii, 2009, no. 1, pp. 96-98 (in Russ.).
2. Munro C.A., Prasad V.S., Midha R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. Am. J. Phys. Med. Rehabil. J. Trauma, 1998, Jul, 45 (1), pp. 116-22.
3. McAllister R., Gilbert S., Calder J., Smith P. The epidemiology and management of upper limbperipheral nerve injuries in modern practice. J. Hand Surg. [Br], 1996, 21 (1), pp. 4-13.
4. Taylor C.A., Braza D., Rice J.B., Dillingham T. The incidence of peripheral nerve injury in extremity trauma. Am. J. Phys. Med. Rehabil, 2008, May, 87 (5), pp. 381-5.
5. Scott W. Wolfe, William C. Pederson, Robert N. Hotchkiss, Scott H. Kozin Green’s Operative Hand Surgery: 2-Volume Set, 6e (Operative Hand Surgery (Green’s)). 6th Edition, 2011
6. Grin’ V.K. et al. The use of autologous mesenchymal stem cells in cardiology and trauma. Zhurn. HAMN Ukraїni, 2011, vol. 17, no.1, pp. 67-75 (in Russ.).
7. Sandra A. Acosta, Naoki Tajiri, Kazutaka Shinozuka et al. Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury. doi: 10.1371/journal.pone.0090953. Published: March 12, 2014.
8. Lu Chen, Ronald Coleman, Ronika Leang et al. Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis. Stem Cell Research & Therapy, 2014. Published online 2014 May 15. doi: 10.1016/j.stemcr.2014.04.005
9. Katare R., Stroemer P., Hicks C., et al. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb. Vasc. Biol, 2014 Feb, 34 (2), pp. 408-18. doi: 10.1161/ATVBAHA.113.302592. Epub 2013, Nov 7.
10. Yang D.Y., Sheu M.L., Su H.L. et al. J. Neurosurg, 2012, Jun, 116 (6), pp. 1357-67. doi: 10.3171/2012.2.JNS111360. Epub 2012 Apr 13.
11. Wang D., Liu X.L., Zhu J.K. et al. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res, 2008 Jan 10, 1188, pp. 44-53. Epub 2007 Oct 18
12. Spejo A.B., Carvalho J.L., Goes A.M., Oliveira A.L. Neuroprotective effects of mesenchymal stem cells on spinal motoneurons following ventral root axotomy: synapse stability and axonal regeneration. Neuroscience, 2013, Oct 10, 250, pp. 715-32. doi: 10.1016/j.neuroscience.2013.07.043. Epub 2013, Jul 27.
13. Reid A.J., Sun M., Wiberg M. et al. Nerve repair with adipose-derived stem cells protects dorsal root ganglia neurons from apoptosis. Neuroscience, 2011, Dec 29, 199, pp. 515-22. doi: 10.1016/j.neuroscience.2011.09.064. Epub 2011, Oct 6
14. Marconi S., Castiglione G., Turano E. et al. Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush. Tissue Eng Part A, 2012 Jun, 18 (11-12), pp. 1264-72. doi: 10.1089/ten.TEA.2011.0491. Epub 2012, Apr 3.
15. Wakitani S., Imoto K., Yamamoto T. et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage, 2002, Mar, 10 (3), pp. 199-206.
16. Masgutov R.F., Bogov A.A. (ml.), Rizvanov A.A. et al. Stem cells from adipose tissue. The biological properties and perspectives of clinical applications. Prakticheskaya meditsina, 2011, no. 55 (in Russ.).
17. Masgutov R.F., Masgutova G.A., Salafutdinov I.I. et al. Stimulation of posttraumatic regeneration of the sciatic nerve of a rat in xenotransplantation of multipotent mesenchymal stromal cells, adipose tissue. Geny&Kletki, 2015, vol. X, no.1 (in Russ.).