T.A. SILANTEVA, A.N. NAKOSKIN, N.V. NAKOSKINA, I.A. TALASHOVA

Russian Ilizarov Center «Restorative Traumatology and Orthopaedics» of the RF Ministry of Healthcare, Kurgan, Russian Federation

 Silanteva T.A. – PhD (medicine), Head of the Laboratory of Morphology

Address: 6 M. Ulyanov St., Kurgan, Russian Federation, 640014, tel.: +7 (3522) 41-52-27, e-mail: tsyl@mail.ru

 To study the bone reparative processes in the area of a hip bone shaft semicircular defect filled with allo- or xeno-transplants obtained from the bone tissue using the original technology.

Material and methods. Experiments were conducted on 18 Wistar male rats aged 6–8 months. The extracellular bone matrix of a rat iliac bone (allotransplant) or the spongy substance of a human femoral head (xeno-transplant) were placed in a half-circular defect in the middle third of a rat femur. Optic microscopic research of the bone blocks from transplantation area was performed.

Results. Histological analysis revealed osteo-integration of both allogenic and xenogenic spongy bone fragments transplanted into the semi-circular rat bone defects. When using allografts, a higher rate of their biodegradation and organotypical rearrangement was noted. In all experiments, the absence of the fibrous encapsulation of the transplant and inflammation of the bone tissue bed was shown.

Conclusion. The obtained histological studies confirm the possibility of using xenogenic bone matrix to replace bone defects.

Key words: bone tissue, allo- and xeno-transplantation, reparative osteogenesis, histology.

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