N.A. KONONOVICH

FSBI Russian Ilizarov Center «Restorative Traumatology and Orthopaedics» of the RF Ministry of Healthcare, Kurgan, Russian Federation

 Kononovich N.A. – Cand. Vet. Sc., Leading Researcher at the Experimental Laboratory

Address: 6 M. Ulyanov St., Kurgan, Russian Federation, 6640014, tel.: +7 (352) 241-52-73, e-mail: n.a.kononovich@mail.ru

To study the body’s biological reaction to implants and calcium diffusion depending on the method of the bioactive layer coating.

Material and methods. During the in vivo experiments in vitro, we studied Ca release kinetics from the surface of implants made of titanium alloy Ti6Al4V with calcium phosphate coating applied by three different technologies. Also, the reaction to implantation was studied.

Results. In case of high frequency magnetron spray, the adhesion properties of the bioactive layer onto the template are lower than in other methods of its application. Calcium diffusion occurs during 21 days. In case of microarc oxidation and plasma spray, Ca release takes place during 28 days and over 140 days, respectively. The use of such implants does not lead to the change of the basic systems’ functions. Locally, an increase of blood circulation takes place as a result of the moderate increase of the vascular tone due to Ca diffusion from the implant surface.

Conclusions. Ca diffusion from the surface of titanium containing implants with calcium phosphate layer depends on the technology of coating application. No negative effect on tissues and body on the whole was observed.

Key words: pre-clinical studies, implant, bioactive spray, calcium, blood circulation.

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