N.A. POZDEYEVA^1,2, L.N. DOMENTYEVA¹, A.Y. VASILYEVA², V.N. OVCHINNIKOVA¹

¹Cheboksary branch IRTC «Eye Microsurgery» named after acad. S.N. Fedorov» MH of RF, 10 prospect Traktorostroiteley, Cheboksary, 428028

²The Autonomous Institution of the Chuvash Republic «Postgraduate Doctors’ Training Institute» of HealthCare and Social Development Ministry, 3 Krasnaya ploshad, Cheboksary, 428032

Pozdeyeva Nadezhda Alexandrovna — candidate of Medical Sciences, deputy director for Science, tel. (8352) 36-90-81, e-mail: npozdeeva@mail.ru^1,2

Domentyeva Luisa Nikolaevna — head of clinical laboratory, tel. (8352)36-90-49, e-mail: npozdeeva@mail.ru¹

Vasilyeva Anastasia Yuryevna — resident of the ophthalmology course, tel. (8352) 36-90-83, e-mail: nastena.stasiya@mail.ru²

Ovchinnikova Valeria Nikolaevna — junior research assistant, tel. (8352) 36-90-83, e-mail: npozdeeva@mail.ru¹

This article describes a method for treating the ocular surface diseases such as aniridic keratopathy, dry eye syndrome, ocular manifestation of Sjogrens syndrome, corneal erosion, upper limbic keratokonjunctivitis and other using autologous patient serum. Optimal scheme of the drug use is show. Technigus of sampling, preparation of material, keeping rules are described. Indications and contraindications for this method are outlined. These research results indicate the high clinical efficacy of autologous serum in ocular surface diseases.

Key words: autulogous serum, tears, aniridic keratopathy, dry eye syndrome, corneal erosion.

 

 

REFERENCES

1.    Fox R.I., Chan R., Michelson J.B. et al. Beneficia effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum, 1984, vol. 27, no. 4, pp. 459-461.

2.    Tsubota K., Goto E., Fujita H. et al. Treatment of dry eye by autologous serum application in Sjögren’s syndrome. Br. J. Ophthalmol, 1999, vol. 83, no. 4, pp. 390-395.

3.    López-García J.S., Rivas L., García-Lozano I., Murube J. Autologous serum eyedrops in the treatment of aniridic keratopathy. Ophthalmology, 2008, vol. 115, no. 2, pp. 262-267.

4.    Volkovich T.K., Imshenetskaya T.A., Morkhat V.I. Primenenie autosyvorotki, aktivirovannoy zimozanom, v kompleksnom lechenii bakterial’nogo keratita: instruktsiya po primeneniyu [Application autosyvorotki activated zymosan in the complex treatment of bacterial keratitis: instruction manual]. Respublika Belarus: Vitebskiy gosudarstvennyy meditsinskiy universitet, 2010.  P. 5.

5.    Adgelon. Kapli glaznye. Instruktsiya po primeneniyu [Adgelon. Eye drops. Instructions for use]. Moscow: ZAO “Endo-Farm-A”, 2009.  52 p.

6.    Kwok A. Futologous serum ters: Why and when to use. American Academy of Optometry, available at: http://www.bostonsight.org/About-Us/Staff/item/1597/Alan-Kwok-OD-FAAO

7.    Kovalevskaya M.A., Maychuk D.Yu., Brzheskiy V.V. et al. Sindrom “krasnogo glaza” [Syndrome  of the “red eye”]. Moscow, 2010. 108 p., il.

8.    Brzheskiy V.V., Somov E.E. Rogovichno-kon»yunktival’nyy kseroz (diagnostika, klinika, lechenie) []. Saint Petersburg, 2003. 119 p.

9.    Schaumberg D.A., Sullivan D.A., Buring J.E., Dana M.R. Prevalence of dry eye syndrome among US women. Am. J. Ophthalmol, 2003, vol. 136, no. 2, pp. 318-326.

10.  Tananuvat N., Daniell M., Sullivan L.J., Yi Q. et al. Controlled study of the use of autologous serum in dry eye patients. Cornea, 2001, vol. 20, no. 8, pp. 802-806.

11.  Noble B.A., Loh R.S., MacLennan S. et al. Comparison of autologous serum eye drops with conventional therapy in a randomized controlled crossover trial for ocular surface disease. Br. J. Ophthalmol, 2004, vol. 88, no. 5, pp. 647-652.

12.  Lee G.A., Chen S.X. Autologous serum in the management of recalcitrant dry eye syndrome. Clin. Experiment. Ophthalmol, 2008, vol. 36, no. 2, pp. 119-222.

13.  Hyon J.Y., Lee Y.J., Yun P.Y. Management of ocular surface inflammation in Sjögren syndrome. Cornea, 2007, vol. 26, no. 9, suppl 1, pp. 13-15.

14.  Noda-Tsuruya T., Asano-Kato N., Toda I., Tsubota K. Autologous serum eye drops for dry eye after LASIK. J. Refract. Surg, 2006, vol. 22, no. 1, pp. 61-66.

15.  Castillo J.M., Casa J.M., Sardiña R.C., Fernández R.M. et al. Treatment of recurrent corneal erosions using autologous serum. Cornea, 2002, vol. 21, no. 8, pp. 781-783.

16.  Tsubota K., Goto E., Shimmura S., Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology, 1999, vol. 106, no. 10, pp. 1984-1989.

17.  Goto E., Shimmura S., Shimazaki J., Tsubota K. Treatment of superior limbic keratoconjunctivitis by application of autologous serum. Cornea, 2001, vol. 20, no. 8, pp. 807-810.

18.  Matsuo H., Tomidokoro A., Tomita G., Araie M. Topical application of autologous serum for the treatment of late-onset aqueous oozing or point-leak through filtering bleb. Eye, 2005, vol. 19, no. 1, pp. 23-28.