F.R. NUHBALA, R.I. GABIDULLINA

Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan

 Contact:

Nuhbala F.R. ― postgraduate student of the Department of Obstetrics and Gynecology named after V.S. Gruzdev

Address: 49 Butlerov Str., 420012, Kazan, Russian Federation, tel. +7-950-313-37-34, e-mail: nuhbala_fikret@mail.ru

 Objective. To analyze the prevalence of KLF5 gene rs11841589 polymorphism variants and to reveal its association with the risk of endometrial cancer.

Material and methods. The study included 161 female residents of the Republic of Tatarstan. The main group consisted of 60 patients with endometrial cancer and the control group – of 101 women without endometrial pathology. The average age was 61.3 (8.8) y.o. in the main group and 65.5 (5.4) y.o. in the control group (р<0.05). Determination of KLF5 gene rs11841589 polymorphism was carried out with the method of real time polymerase chain reaction. The χ2 test was performed and the odds ratio indicator was evaluated.

Results. It was established that the presence of the G allele and the G/G genotype of the KLF5 gene rs18841589 polymorphism does not increase the risk of endometrial cancer in women living in the Republic of Tatarstan. G allele (79.7% against 72.5%; χ2= 2.21, p = 0.14; OR = 0.67, 95% CI 0.40–1.14) and G/G genotype (55.0% against 66.3%; χ2= 2.08, p = 0.35; OR = 0.62, 95% CI 0.32–1.19) occurs in the endometrial cancer group and in the control group without statistical significance. The prevalence of alleles and genotypes of the KLF5 gene was comparable with the European one.

Conclusion. The study revealed that the associations of KLF5 gene rs18841589 polymorphism with the risk of endometrial cancer in the 161 female residents of the Republic of Tatarstan were not identified.

Key words: endometrial cancer, polymorphism, gene.

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