N.Ya. SENCHENKO

Irkutsk branch of Eye Microsurgery Federal State Institution named after Acad. S.N. Fyodorov, 337 Lermontov Str., Irkutsk, Russian Federation, 664017

Senchenko N.Ya. — PhD (Medicine), Head of Surgical Department, tel. +7-914-941-30-93, e-mail: [email protected]

14 children (28 eyes) with congenital aniridia and cataract, aged from 5 to 18 years, were operated and examined. The artificial iris-lens complex «MIOL-Iris» was implanted to these patients. Follow-up period was 5 years. An increase in the resolution of the visual system was noted, a satisfactory cosmetic effect was achieved in all children, which generally confirms the effectiveness of this treatment. The revealed complications in the postoperative period require solving the issues of social and medical rehabilitation of such patients.

Key words: congenital aniridia, artificial iris-lens diaphragm.

REFERENCES

1. Beattie P. A consideration of aniridia, with pedigree. Br. J. Ophthalmol., 1947, vol. 31, p. 649.
2. Nelson L.B., Spaeth G.L., Nowinski T.S. et al. Aniridia: A review. Surv. Ophthalmol., 1984, vol. 28, p. 621.
3. Dansault A., David G., Schmartz C. et al. Three new PAX6 mutations including one causing an unusual ophthalmic phenotype associated with neurodevelopmental abnormalities. Mol. Vis., 2007, vol. 13, pp. 511-523.
4. Prosser J., van Heyningen V. PAX6 mutations reviewed. Hum. Mutat., 1998, vol. 11, no. 2, pp. 93-108.
5. Adeoti C.O., Afolabi A.A. Bilateral sporadic aniridia: review of management. Clin. Ophthalmol., 2010, vol. 4, pp. 1085-1089.
6. Kokotas H., Petersen M.B. Clinical and molecular aspects of aniridia. Clin. Genet., 2010, vol. 77, no. 5, pp. 409-420.
7. Lee H., Khan R., O׳Keefe M. Aniridia: current pathology and management. Acta. Ophthalmol., 2008, vol. 86, no. 7, pp. 708-715.
8. McCulley T.J., Mayer K., Dahr S.S. et al. Aniridia and optic nerve hypoplasia. Eye (Lond), 2005, vol. 19, no. 7, pp. 762–764.
9. Jusufovic V., Cabric E., Popovic-Beganovic A. Treatment of congenital aniridia associated with subluxated infantile cataract. Med. Arh., 2014, vol. 68, no. 3, pp. 212-214.
10. Nelson L.B., Neuhann I.M., Neuhann T.F. Cataract surgery and aniridia. Curr. Opin. Ophthalmol., 2010, vol. 21, Issul l, pp. 60-64.
11. Stefan C., Niculescu C. Congenital aniridia and cataract. Ophthalmolgia, 1994, vol. 38, no. 2, pp. 141-143.
12. Davis J., Duncan M.K., Robison W.G. et al. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J. Cell. Sci., 2003, vol. 116, pp. 2157-2167.
13. Ramaesh K., Ramaesh T., Dutton G.N. et al. Evolving concepts on the pathogenetic mechanisms of aniridia related keratopathy. Int. J. Biochem. Biol., 2005, vol. 37, pp. 547-557.
14. Gramer E., Reiter C., Gramer G. Glaucoma and frequency of ocular and general diseases in 30 patients with aniridia: a clinical study. Eur. J. Ophthalmol., 2012, vol. 22, no. 1, pp. 104-110.
15. Saltzmann R.M., Reinecke S., Lin X.et al. Long-term outcomes of a pseudo 360-degree trabeculotomy ab externo technique for congenital glaucoma at children′s medical center. Clin. Ophthalmol., 2012, no. 6, pp. 963-965.
16. Wallace D.K., Plager D.A., Snyder S.K. et al. Surgical results of secondary glaucomas in childhood. Ophthalmology, 1998, vol. 105, no. 1, pp. 101-111.
17. Walton D.S. Aniridic glaucoma: The result of goniosurgery to prevent and treat this problem. Trans. Am. Ophthalmol. Soc., 1986, vol. 84, p. 59.
18. D’yachenko Yu.N., Egorov V.V., Sorokin E.L. Efficiency and problems of reconstructive surgery of the eye with aniridia. Oftal’mokhirurgiya, 2013, no. 4, pp. 82-85 (in Russ.).
19. Pozdeeva N.A. The new model of artificial iridohrustalikovoy aperture correction of large defects of the iris (the clinical and functional results of implantation). Vestnik oftal’mologii, 2013, no. 6, pp. 38-42 (in Russ.).
20. Pozdeeva N.A. Sistema meditsinskoy reabilitatsii patsientov s aniridiey: avtoref. dis. … d-ra med. nauk [The system of medical rehabilitation of patients with aniridia. Synopsis of dis. Dr Med. Sci]. Moscow, 2014. 429 p.
21. Fechin O.B., Shilovskikh O.V., Laptev B.V. Korrektsiya polnoy i chastichnoy aniridii s ispol’zovaniem kompleksa «Iskusstvennaya raduzhka + IOL» [Correction of complete and partial aniridia with complex «Artificial Iris + IOL»]. Sovremennye tekhnologii kataraktal’noy i refraktsionnoy khirurgii, 2012. Moscow, 2012. Pp.157-161.
22. Koch K.R., Heindl L.M., Cursiefen C. Artificial iris devices: benefits, limitations, and management of complications. J. Cataract Refract. Surg., 2014, vol. 40, no. 3, pp. 376-82.
23. Sikder S., Davis S.W., Patel V.P. et al. Complications and management of NewColorIris implantation in phakic eyes. J. Refract. Surg., 2011, vol. 27, pp. 239-240.
24. Thomas B.C., Rabsilber T.M., Auffarth G.U. Aniridia – IOL and artificial iris reconstruction. Klin. Monbl. Augenheilkd., 2013, vol. 230, no. 8, pp. 786-790.