F.A. KHABIROV^1,2, T.I.  KHAYBULLIN^1,2, E.V. GRANATOV²

KSMA ― Branch Campus of the FSBEI FPE RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012

Republican Clinical Neurology Center of the MH of RT, 13 Vatutin Str., Kazan, Russian Federation, 420021

 Khabirov F.A. — D. Med. Sc., Professor, Head of the Department of Neurology and Manual therapy, Chief Physician of Republican Clinical Neurology Center, tel. (843) 278-88-29, e-mail: rkdcdz@rkbvl.ru

Khaybullin T.I. — Cand. Med. Sc., Associate Professor of the Department of Neurology and Manual therapy, neurologist, tel. (843) 278-88-29, e-mail: timuur@gmail.com

Granatov E.V. — Cand. Med. Sc., neurologist, tel. (843) 278-88-29, e-mail: rkdcdz@rkbvl.ru

 Assessment of efficacy and safety of metabolic therapy (MT), including niacinamide, cocarboxylase, cyanocobalamin, disodium adenosine triphosphate trihydrate in treatment of recurrent vertebrogenic lumbosacral radiculopathies (RVLR) is conducted. This placebo-controlled clinical trial enrolled 40 patients with RVLR L₅ and/or S₁ who were randomized to 2 parallel groups. In group 1 (G1: n=20, age 44,3 (7,98) years, M/F — 55/45%) patients were treated with MT and basic therapy (diclofenac sodium 100 mg/day №10 + tizanidine 6 mg/day №24), in group 2 (G2: n=20, age 45,3 (8,25) years, M/F — 60/40%) patients received placebo (0,9% NaCl solution) and basic therapy. Before and after 30 days of treatment the condition of patients was examined clinically on a 5-point verbal rating scale (5 BVSH), Oswestry disability index (ERI) and by means of neurophysiological methods. After treatment in G1 was registered marked improvement on 5-PVRS (p=0,046) and ODI (in G1 it declined from 42[36;49]% to 26[18;34]%, in G2 from 38[30;50]% to 34[24;38]%; p=0,04). More significant regression of total neurophysiological abnormalities was observed in G1 (77,8 vs. 35,3%; p=0,02). Also, it was not possible to identify significant between-group differences in the regression of certain neurophysiological abnormalities (p>0,05) and complete leveling of neurophysiological abnormalities (22,2 vs. 5,9%; p=0,35). Tolerability and safety of treatment in both groups was satisfactory. Therefore, MT added to basic therapy increases treatment efficacy of RVLR.

Key words: radiculopathy, metabolic therapy, treatment, efficacy, safety.

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