A.A. NIZhEVICh, E.N. AKhMADEEVA, E.S. KUChINA, V.U. SATAEV

Bashkir State Medical University, 3 Lenina St., Ufa, Russian Federation, 450000

Nizhevich A.A. — D. Med. Sc., Professor, Assistant of the Department of Hospital Pediatrics, tel. (347) 255-73-26, e-mail: aanj@yandex.ru

Akhmadeeva E.N. — D. Med. Sc., Professor, Head of the Department of Hospital Pediatrics, tel. (347) 255-73-26; e-mail: pediatr@ufanet.ru

Kuchina E.S. — Postgraduate Student of the Department of Hospital Pediatrics, tel. (347) 255-73-26, e-mail: k-ufa@mail.ru

Sataev V.U. — D. Med. Sc., Professor of the Department of Pediatric Surgery, Orthopedics and Anesthesiology, tel. (347) 255-73-26; e-mail: sataev.valery @ gmail.com

The comparison of the effectiveness of the pilot scheme of Helicobacter pylori sequential eradication therapy in 176 children within the age group from 12 to 17 (the average age being 14,7±1,63) with the anti – helicobacter therapy classical scheme therapy was carried out. The Helicobacter pylori eradication was attained in 81 (93,1%) patients having undergone the sequential therapy and in 67 (75,3%) patients having received the standard triple therapy. The authenticity of the data obtained for the above groups of patients has been confirmed by means of the statistic analysis.

Key words: Helicobacter pylori, eradication, children, sequential therapy, chronic gastroduodenit.

 

 

REFERENCES

1. Shcherbakov P.L., Shcherbakov V.S., Kashnikov E.A., Kornienko P.L. Treatment of diseases associated with infection Helicobacter pylori. Lechashchiy vrach, 2010. no. 7, pp. 6-11 (in Russ.).

2. Podusenko V.V. Rasprostranennost’ i osobennosti techeniya khelikobakterioza u shkol’nikov Primorskogo kraya: avtoref. dis. … kand. med. nauk [Prevalence and characteristics of schoolchildren helikobakterioza Primorye Territory. Synopsis of the dis. of PhD of med. sci.]. Moscow, 2006. 19 p.

3. Koletzko S., Jones N.L., Goodman K.J. et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J. Pediatr. Gastroenterol. Nutr, 2011, vol. 53, no. 2, pp. 230-43.

4. Glotova O.M. Frequency of occurrence and characteristics of gastroduodenitis associated with Helicobacter pylori, schoolchildren of Chita city. Byulleten’ VSNTs SO RAMN, 2009, no. 4, pp. 13-16 (in Russ.).

5. Isaeva G.Sh. H. pylori resistance to antimicrobial agents and methods for its determination. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya, 2010, no. 1, pp. 57-66 (in Russ.).

6. Kudryavtseva L.V. Helicobacter pylori antibiotic resistance state in Russia. Eksperimental’naya i klinicheskaya gastroenterologiya, 2003, no. 3, pp. 7-8 (in Russ.).

7. Megraud F. Helicobacter pylori and antibiotic resistance. Gut, 2007, vol. 56, pp. 1502-1507.

8. Falls G., Steininger H., Kranzlein J. et al. Antigastric autoantibodies in Helicobacter pylori infection. Gut, 1997, vol. 41 (suppl.), pp. 619-623.

9. Isakov V.A., Domaradskiy I.V. Khelikobakterioz [Helicobacter pylori antibiotic resistance state in Russia]. Moscow: Medpraktika-M, 2003. Pp. 79-97.

10. Shcherbakov A.P., Shcherbakov P.L. Doing H. pylori infection in children (scientific advice ESPGHAN and NASPGHAN 2010). Lechashchiy vrach, 2011, no. 6, pp. 46-58.

11. Malfertheiner P., Megraud F., O’Moran C. et al. Current concepts in the management of Helicobacter pylori infection — The Maastricht III Consensus Report. Gut, 2006, no. 10, pp. 772-781.

12. Tkachenko E.I., Uspenskiy Yu.P., Baryshnikova N.V. Optimizing treatment of diseases associated with Helicobacter pylori. Vrach, 2012, no. 1, pp. 36-38 (in Russ.).

13. Kornienko E.A., Shcherbakov P.L. Experience of using Pariet (rabeprazole) in children up to 10 years old. Rossiyskiy meditsinskiy zhurnal, 2004, vol. 12, no. 3, pp. 40-43 (in Russ.).

14. Andersson T., Hassall E., Lundborg P. et al. Pharmacokinetics of orally administered omeprazole in children. Am. J. Gastroent, 2000, vol. 95, pp. 3101-3106.

15. Kornienko E.A., Klochko O.G. Comparative efficacy of proton pump inhibitors in children. Eksperimental’naya i klinicheskaya gastroenterologiya, 2003, no. 6, pp. 72-75 (in Russ.).

16. Khomeriki N.M., Khomeriki S.G. Some mechanisms of adverse effects of H. pylori therapy and ways of their correction. Consilium medicum, 2005, no. 2 (Appendix), pp. 22-25 (in Russ.).

17. Maev I.V., V’yuchnova E.S., Petrova E.G. Side effects of modern therapy of H. pylori. Klinicheskaya meditsina, 2002, no. 6, pp. 7-12.

18. Vaira D., Zullo A., Vakil N. et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial. Ann. Int. Med, 2007, vol. 146, no. 8, pp. 556-563.

19. Francavilla R., Lionetti E., Castellaneta S.P. et al. Improved efficacy of 10-Day sequential treatment for Helicobacter pylori eradication in children: a randomized trial. Gastroenterology, 2005, vol. 129, no. 5, pp. 1414-1419.

20. Vakil N. Helicobacter pylori Eradication: Sequential and Traditional Therapy. Gastroenterol. Hepatol, 2009, vol. 5, pp. 59-64.

21. Khurana R., Fischbach L., Chiba N. et al. Meta-analysis: Helicobacter pylori eradication treatment efficacy in children. Aliment. Pharmacol. Ther, 2007, vol. 25, no. 5, pp. 523-535.

22. Rebrova O.Yu. Statisticheskiy analiz meditsinskikh dannykh [Statistical analysis of medical data]. Moscow: Media-Sfera, 2002. 312 p.