V.I. PREKINA, I.Yu. CHERNOVA, M.V. ESINA, O.N. EFREMOVA

National Research Mordovia State University named after N.P. Оgarev, Saransk

Contact details:

Prekina V.I. ― PhD (medicine), Associate Professor of the Department of Outpatient Therapy

Address: 68 Bolshevistskaya Str., Saransk, Russian Federation, 430005, e-mail: [email protected]

  Objective ― to study the duration of QT interval in patients with subacute ischemic stroke.

Material and methods. The study included 176 patients with arterial hypertension. The main group consisted of 102 patients with ischemic stroke in the subacute period, the control group ― 74 patients without stroke. The duration of the QT interval was estimated from Holter monitoring (HM) data during the day. The comparability of the measurements results of the QT interval by the standard resting ECG and HM was determined in 20 patients in the control group.

Results. Transient increase of QT interval duration was revealed in patients with stroke. Elongated QT was recorded more often during wakefulness, which suggests a sympathoadrenal mechanism of its elongation. There was a direct correlation of the average daily QTc with the severity of stroke and blood glucose levels. The average QTc was correlated with the total duration of the episodes of the prolonged QTc interval. In the automatic analysis of the QT interval, its duration was slightly (10 MS) less than on the resting ECG.

Conclusion. In ischemic stroke in the subacute period, the electrical instability of the myocardium is increased, manifested in transient prolongation of the QT interval. Major risk factors for the QT lengthening were the stroke severity and the hyperglycemia level. Along with the average daily QTc, the total duration of the episodes of the transient extension of the QTc may be considered the diagnostic parameter of the extended QT according to the HM data. Automated analysis of QT interval is comparable with the manual measurement on a resting ECG.

Key words: QT interval duration, ischemic stroke, risk factors for QT interval prolongation.

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