O.V. BORISOVA, E.V. BOYKO

 Samara State Medical University, Samara

Contact details:

Borisova O.V. — MD, Professor, Head of the Department of Children’s Infections

Address: 89 Chapaevskaya St., Samara, Russian Federation, 443099, tel.: +7 (846) 374-10-04 (4696), e-mail: o.v.borisova@samsmu.ru

 The article discusses one of the main complications in acute intestinal infections in children — acute kidney injury (AKI), which is often a life-threatening condition that occurs due to acute loss of kidney function. In the future, these patients may develop chronic kidney disease.

The main pathogenetic aspects of this complication in children and the mechanisms of its development are analyzed; the frequency of occurrence is shown according to the data of different authors. Transient renal dysfunction occurs in 21.9–41.6% of children with acute intestinal infections. Hemolytic uremic syndrome is the leading cause of acute renal failure in children under 3 years of age. Aspects of the AKI diagnosis at the present stage are presented, including endogenous markers for assessing the glomerular filtration rate (GFR). The importance of early diagnosis of AKI is shown, and the need to introduce new standardized criteria for calculating GFR is substantiated.

Key words: acute intestinal infections, acute kidney injury, children.

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